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miR-495 and miR-5688 are down-regulated in non-small cell lung cancer under hypoxia to maintain interleukin-11 expression

miR-495 and miR-5688 are down-regulated in non-small cell lung cancer under hypoxia to maintain interleukin-11 expression
Posted by Rachael

Background: Hypoxia is a hallmark of cancer and is associated with poor prognosis. However, the molecular mechanism by which hypoxia promotes tumor development is still unclear. MicroRNAs dysregulation has been shown to play an important role in the tumor and the tumor micro. Here, we investigated the role of miR-495 and miR-5688 in lung cancer of human non-small cell (NSCLC) and their underlying mechanisms.


Methods: The expression level of miR-495 and miR-5688 in human NSCLC tissue specimens was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Deferoxamine (DFO) is used to determine whether the regulation of miR-495 and miR-5688 under hypoxia depends on the hypoxia-inducible factor 1-alpha (HIF-1α).

Furthermore, the function of miR-495 and miR-5688 in tumor progression was evaluated using colony formation, 3- (4,5-dimethylthiazol-2-yl) -5- (3-carboxymethoxyphenyl) -2- (4-sulfophenyl) -2H -tetrazolium (MTS), wound healing, transwell test, and the xenograft model. Two algorithms, PicTAR and Targetscan, used to predict the two miRNAs target gene is, and dual-luciferase reporter assay was performed to confirm the target. Tests are two-tailed paired t, Pearson correlation analysis and Fisher probability test conducted for statistical analysis.


Results: The two miRNAs, miR-495 and miR-5688, was found to participate in the development of NSCLC under hypoxia. They were down-regulated in NSCLC tissue compared to normal tissue. We determined that hypoxia causes down-regulation of miR-495 and miR-5688 in NSCLC cells, independent of HIF-1α and energy metabolism of cells. In addition, miR-495 and miR-5688 suppressed cell proliferation, migration and invasion in vitro

miR-495 and miR-5688 are down-regulated in non-small cell lung cancer under hypoxia to maintain interleukin-11 expression
miR-495 and miR-5688 are down-regulated in non-small cell lung cancer under hypoxia to maintain interleukin-11 expression

. The NSCLC xenograft models indicate that miR-495 and miR-5688 inhibits tumor formation in vivo. Interestingly, we found that miR-495 and miR-5688 have the same target, interleukin-11 (IL-11). Human recombinant IL-11 is counteracted the effects of miR-495 and miR-5688 in NSCLC cells, suggesting that miR-495 and miR-5688 held their tumor suppressor role by pressing IL-11 expression.

Conclusion: We found hypoxia down-regulated the expression level of miR-495 and miR-5688 in NSCLC to increase IL-11 expression and tumor progression, suggesting that miR-495 / miR-5688 / IL-11 axis can serve as a therapeutic target and a potential biomarker for NSCLC.

Variants in IL 6ST selectively IL – 11 signal defects in the Human and mouse Gp130 cytokine receptor subunit encoded by the IL 6ST is a cytokine receptors together for ten of IL -6 family. We describe non-identical homozygous variant in IL 6ST (p.R281Q) in patients with craniosynostosis and maintain primary teeth. We characterize the effects of variants in cytokine signaling in vitro using cell lines and cells transfected patient-derived primary and support these findings using mice models with appropriate genome -edited variant Il6st that p.R279Q.

Rat Interleukin 17B (IL17B) ELISA Kit

DLR-IL17B-Ra-48T 48T
EUR 570
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 17B (IL17B) in samples from serum, plasma or other biological fluids.

Rat Interleukin 17B (IL17B) ELISA Kit

DLR-IL17B-Ra-96T 96T
EUR 739.2
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 17B (IL17B) in samples from serum, plasma or other biological fluids.

Human Interleukin 17B (IL17B) ELISA Kit

RDR-IL17B-Hu-48Tests 48 Tests
EUR 549.6

Human Interleukin 17B (IL17B) ELISA Kit

RDR-IL17B-Hu-96Tests 96 Tests
EUR 759.6

Mouse Interleukin 17B (IL17B) ELISA Kit

RDR-IL17B-Mu-48Tests 48 Tests
EUR 564

Mouse Interleukin 17B (IL17B) ELISA Kit

RDR-IL17B-Mu-96Tests 96 Tests
EUR 781.2

Rat Interleukin 17B (IL17B) ELISA Kit

RDR-IL17B-Ra-48Tests 48 Tests
EUR 594

Rat Interleukin 17B (IL17B) ELISA Kit

RDR-IL17B-Ra-96Tests 96 Tests
EUR 822

Human Interleukin 17B (IL17B) ELISA Kit

RD-IL17B-Hu-48Tests 48 Tests
EUR 526.8

Human Interleukin 17B (IL17B) ELISA Kit

RD-IL17B-Hu-96Tests 96 Tests
EUR 727.2

Mouse Interleukin 17B (IL17B) ELISA Kit

RD-IL17B-Mu-48Tests 48 Tests
EUR 540

Mouse Interleukin 17B (IL17B) ELISA Kit

RD-IL17B-Mu-96Tests 96 Tests
EUR 746.4

Rat Interleukin 17B (IL17B) ELISA Kit

RD-IL17B-Ra-48Tests 48 Tests
EUR 567.6

Rat Interleukin 17B (IL17B) ELISA Kit

RD-IL17B-Ra-96Tests 96 Tests
EUR 786

Interleukin 17B (IL17B) Antibody

20-abx101512
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 17B (IL17B) Antibody

20-abx101513
  • EUR 526.80
  • EUR 159.60
  • EUR 1496.40
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 17B (IL17B) Antibody

abx038115-100ug 100 ug
EUR 469.2

Interleukin 17B (IL17B) Antibody

20-abx330118
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Interleukin 17B (IL17B) Antibody

20-abx216191
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Interleukin 17B (IL17B) Antibody

abx234226-100ug 100 ug
EUR 661.2

Interleukin 17B (IL17B) Antibody

20-abx173104
  • EUR 978.00
  • EUR 510.00
  • 1 mg
  • 200 ug

Interleukin 17B (IL17B) Antibody

20-abx173105
  • EUR 1045.20
  • EUR 543.60
  • 1 mg
  • 200 ug

Interleukin 17B (IL17B) Antibody

20-abx177117
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Interleukin 17B (IL17B) Antibody

20-abx177118
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Recombinant Interleukin 17B (IL17B)

4-RPB700Hu01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 17B expressed in: E.coli

Recombinant Interleukin 17B (IL17B)

4-RPB700Ra01
  • EUR 610.30
  • EUR 286.80
  • EUR 1958.59
  • EUR 732.86
  • EUR 1345.73
  • EUR 483.60
  • EUR 4716.48
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Interleukin 17B expressed in: E.coli

Rat Interleukin 17B (IL17B) Protein

20-abx067473
  • EUR 844.80
  • EUR 343.20
  • EUR 2631.60
  • EUR 1011.60
  • EUR 610.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Interleukin 17B (IL17B) Protein

20-abx067475
  • EUR 777.60
  • EUR 326.40
  • EUR 2331.60
  • EUR 910.80
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Interleukin 17B (IL17B) Protein

20-abx653985
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Interleukin 17B (IL17B) Protein

20-abx653986
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Interleukin 17B (IL17B) ELISA Kit

20-abx152021
  • EUR 8534.40
  • EUR 4550.40
  • EUR 1054.80
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Interleukin 17B (IL17B) ELISA Kit

20-abx155721
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Interleukin 17B (IL17B) ELISA Kit

20-abx154238
  • EUR 8684.40
  • EUR 4626.00
  • EUR 1074.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Interleukin 17B (IL17B) ELISA Kit

abx574703-96tests 96 tests
EUR 801.6

Mouse Interleukin 17B (IL17B) ELISA Kit

abx574963-96tests 96 tests
EUR 801.6

Human Interleukin 17B (IL17B) CLIA Kit

20-abx190244
  • EUR 9493.20
  • EUR 5058.00
  • EUR 1167.60
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Interleukin 17B (IL17B) CLIA Kit

20-abx190529
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Interleukin 17B (IL17B) CLIA Kit

20-abx190699
  • EUR 10131.60
  • EUR 5396.40
  • EUR 1243.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Interleukin-17B(IL17B) ELISA kit

CSB-EL011598MO-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin-17B (IL17B) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Interleukin-17B(IL17B) ELISA kit

1-CSB-EL011598MO
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin-17B(IL17B) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Il17b/ Interleukin-17B ELISA Kit

E0754Mo 1 Kit
EUR 655.2

Interleukin 17B (IL17B) Polyclonal Antibody (Human)

4-PAB700Hu01
  • EUR 286.80
  • EUR 2869.20
  • EUR 717.60
  • EUR 358.80
  • EUR 253.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 17B (IL17B)

Interleukin 17B (IL17B) Polyclonal Antibody (Rat)

4-PAB700Ra01
  • EUR 301.20
  • EUR 3106.80
  • EUR 771.60
  • EUR 380.40
  • EUR 259.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Interleukin 17B (IL17B)

Human IL17B(Interleukin-17B) ELISA Kit

EH2104 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Human IL17B/ Interleukin-17B ELISA Kit

E1264Hu 1 Kit
EUR 685.2

Human Interleukin- 17B, IL17B ELISA KIT

ELI-06753h 96 Tests
EUR 988.8

Mouse Interleukin- 17B, Il17b ELISA KIT

ELI-06754m 96 Tests
EUR 1038

Human Interleukin 17B (IL17B)CLIA Kit

SCB700Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Human Interleukin 17B (IL17B)CLIA Kit

SCB700Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Human Interleukin 17B (IL17B)CLIA Kit

SCB700Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Human Interleukin 17B (IL17B)CLIA Kit

SCB700Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Human Interleukin 17B (IL17B) CLIA Kit

4-SCB700Hu
  • EUR 6837.60
  • EUR 3673.20
  • EUR 896.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Interleukin 17B (IL17B)Serum, plasma and other biological fluids

Mouse Interleukin 17B (IL17B)CLIA Kit

SCB700Mu-10x96wellstestplate 10x96-wells test plate
EUR 6965.86
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Mouse Interleukin 17B (IL17B)CLIA Kit

SCB700Mu-1x48wellstestplate 1x48-wells test plate
EUR 678.84
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Mouse Interleukin 17B (IL17B)CLIA Kit

SCB700Mu-1x96wellstestplate 1x96-wells test plate
EUR 918.34
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Mouse Interleukin 17B (IL17B)CLIA Kit

SCB700Mu-5x96wellstestplate 5x96-wells test plate
EUR 3772.51
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Mouse Interleukin 17B (IL17B) CLIA Kit

4-SCB700Mu
  • EUR 7026.00
  • EUR 3772.80
  • EUR 919.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Interleukin 17B (IL17B)Serum, plasma and other biological fluids

Rat Interleukin 17B (IL17B)CLIA Kit

SCB700Ra-10x96wellstestplate 10x96-wells test plate
EUR 7342.85
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Rat Interleukin 17B (IL17B)CLIA Kit

SCB700Ra-1x48wellstestplate 1x48-wells test plate
EUR 709.88
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Rat Interleukin 17B (IL17B)CLIA Kit

SCB700Ra-1x96wellstestplate 1x96-wells test plate
EUR 962.69
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Rat Interleukin 17B (IL17B)CLIA Kit

SCB700Ra-5x96wellstestplate 5x96-wells test plate
EUR 3972.1
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Rat Interleukin 17B (IL17B) CLIA Kit

4-SCB700Ra
  • EUR 7404.00
  • EUR 3973.20
  • EUR 963.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Rat Interleukin 17B (IL17B)Serum, plasma and other biological fluids

Human Interleukin 17B (IL17B) ELISA Kit

SEB700Hu-10x96wellstestplate 10x96-wells test plate
EUR 5402.92
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Human Interleukin 17B (IL17B) ELISA Kit

SEB700Hu-1x48wellstestplate 1x48-wells test plate
EUR 550.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Human Interleukin 17B (IL17B) ELISA Kit

SEB700Hu-1x96wellstestplate 1x96-wells test plate
EUR 734.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Human Interleukin 17B (IL17B) ELISA Kit

SEB700Hu-5x96wellstestplate 5x96-wells test plate
EUR 2945.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Human Interleukin 17B (IL17B) ELISA Kit

4-SEB700Hu
  • EUR 5463.60
  • EUR 2886.00
  • EUR 735.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Interleukin 17B (IL17B) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.

Mouse Interleukin 17B (IL17B) ELISA Kit

SEB700Mu-10x96wellstestplate 10x96-wells test plate
EUR 5552.14
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Mouse Interleukin 17B (IL17B) ELISA Kit

SEB700Mu-1x48wellstestplate 1x48-wells test plate
EUR 562.42
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Mouse Interleukin 17B (IL17B) ELISA Kit

SEB700Mu-1x96wellstestplate 1x96-wells test plate
EUR 752.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Mouse Interleukin 17B (IL17B) ELISA Kit

SEB700Mu-5x96wellstestplate 5x96-wells test plate
EUR 3024.07
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Mouse Interleukin 17B (IL17B) ELISA Kit

4-SEB700Mu
  • EUR 5612.40
  • EUR 2965.20
  • EUR 752.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Interleukin 17B (IL17B) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.

Rat Interleukin 17B (IL17B) ELISA Kit

SEB700Ra-10x96wellstestplate 10x96-wells test plate
EUR 5850.59
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Rat Interleukin 17B (IL17B) ELISA Kit

SEB700Ra-1x48wellstestplate 1x48-wells test plate
EUR 586.99
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Rat Interleukin 17B (IL17B) ELISA Kit

SEB700Ra-1x96wellstestplate 1x96-wells test plate
EUR 787.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Rat Interleukin 17B (IL17B) ELISA Kit

SEB700Ra-5x96wellstestplate 5x96-wells test plate
EUR 3182.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.

Rat Interleukin 17B (IL17B) ELISA Kit

4-SEB700Ra
  • EUR 5911.20
  • EUR 3122.40
  • EUR 787.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Interleukin 17B (IL17B) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.

Mouse Interleukin 17B ELISA Kit (IL17B)

RK02934 96 Tests
EUR 625.2

Rat Interleukin 17B ELISA Kit (IL17B)

RK03755 96 Tests
EUR 625.2

Interleukin 17B (IL17B) Polyclonal Antibody (Human), APC

4-PAB700Hu01-APC
  • EUR 399.60
  • EUR 3735.60
  • EUR 1046.40
  • EUR 507.60
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 17B (IL17B). This antibody is labeled with APC.

Interleukin 17B (IL17B) Polyclonal Antibody (Human), Biotinylated

4-PAB700Hu01-Biotin
  • EUR 363.60
  • EUR 2809.20
  • EUR 836.40
  • EUR 442.80
  • EUR 259.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 17B (IL17B). This antibody is labeled with Biotin.

Interleukin 17B (IL17B) Polyclonal Antibody (Human), Cy3

4-PAB700Hu01-Cy3
  • EUR 483.60
  • EUR 4930.80
  • EUR 1345.20
  • EUR 627.60
  • EUR 294.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 17B (IL17B). This antibody is labeled with Cy3.

Interleukin 17B (IL17B) Polyclonal Antibody (Human), FITC

4-PAB700Hu01-FITC
  • EUR 344.40
  • EUR 3012.00
  • EUR 860.40
  • EUR 430.80
  • EUR 230.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 17B (IL17B). This antibody is labeled with FITC.

Interleukin 17B (IL17B) Polyclonal Antibody (Human), HRP

4-PAB700Hu01-HRP
  • EUR 366.00
  • EUR 3256.80
  • EUR 926.40
  • EUR 459.60
  • EUR 243.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 17B (IL17B). This antibody is labeled with HRP.

Interleukin 17B (IL17B) Polyclonal Antibody (Human), PE

4-PAB700Hu01-PE
  • EUR 344.40
  • EUR 3012.00
  • EUR 860.40
  • EUR 430.80
  • EUR 230.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 17B (IL17B). This antibody is labeled with PE.

Interleukin 17B (IL17B) Polyclonal Antibody (Rat), APC

4-PAB700Ra01-APC
  • EUR 422.40
  • EUR 4059.60
  • EUR 1126.80
  • EUR 540.00
  • EUR 267.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Interleukin 17B (IL17B). This antibody is labeled with APC.

Interleukin 17B (IL17B) Polyclonal Antibody (Rat), Biotinylated

4-PAB700Ra01-Biotin
  • EUR 379.20
  • EUR 3046.80
  • EUR 896.40
  • EUR 465.60
  • EUR 265.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Interleukin 17B (IL17B). This antibody is labeled with Biotin.

Interleukin 17B (IL17B) Polyclonal Antibody (Rat), Cy3

4-PAB700Ra01-Cy3
  • EUR 513.60
  • EUR 5362.80
  • EUR 1453.20
  • EUR 670.80
  • EUR 306.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Interleukin 17B (IL17B). This antibody is labeled with Cy3.

Interleukin 17B (IL17B) Polyclonal Antibody (Rat), FITC

4-PAB700Ra01-FITC
  • EUR 362.40
  • EUR 3271.20
  • EUR 925.20
  • EUR 456.00
  • EUR 237.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Interleukin 17B (IL17B). This antibody is labeled with FITC.

Interleukin 17B (IL17B) Polyclonal Antibody (Rat), HRP

4-PAB700Ra01-HRP
  • EUR 386.40
  • EUR 3537.60
  • EUR 996.00
  • EUR 488.40
  • EUR 252.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Interleukin 17B (IL17B). This antibody is labeled with HRP.

Interleukin 17B (IL17B) Polyclonal Antibody (Rat), PE

4-PAB700Ra01-PE
  • EUR 362.40
  • EUR 3271.20
  • EUR 925.20
  • EUR 456.00
  • EUR 237.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Interleukin 17B (IL17B). This antibody is labeled with PE.

ELISA kit for Human IL17B (Interleukin 17B)

ELK2702 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Interleukin 17B from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Mouse IL17B (Interleukin 17B)

ELK4007 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Interleukin 17B from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Rat IL17B (Interleukin 17B)

ELK5674 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Interleukin 17B from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Interleukin 17B (IL17B) Polyclonal Antibody (Human), APC-Cy7

4-PAB700Hu01-APC-Cy7
  • EUR 656.40
  • EUR 7327.20
  • EUR 1948.80
  • EUR 872.40
  • EUR 372.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 17B (IL17B). This antibody is labeled with APC-Cy7.

Interleukin 17B (IL17B) Polyclonal Antibody (Rat), APC-Cy7

4-PAB700Ra01-APC-Cy7
  • EUR 702.00
  • EUR 7975.20
  • EUR 2110.80
  • EUR 937.20
  • EUR 391.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Interleukin 17B (IL17B). This antibody is labeled with APC-Cy7.

Mini Samples Mouse Interleukin 17B (IL17B) ELISA Kit

MEB700Mu-10x96wellstestplate 10x96-wells test plate
EUR 6628.14
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Interleukin 17B (IL17B).

Mini Samples Mouse Interleukin 17B (IL17B) ELISA Kit

MEB700Mu-1x48wellstestplate 1x48-wells test plate
EUR 651.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Interleukin 17B (IL17B).

Mini Samples Mouse Interleukin 17B (IL17B) ELISA Kit

MEB700Mu-1x96wellstestplate 1x96-wells test plate
EUR 878.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Interleukin 17B (IL17B).

Mini Samples Mouse Interleukin 17B (IL17B) ELISA Kit

MEB700Mu-5x96wellstestplate 5x96-wells test plate
EUR 3593.72
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Interleukin 17B (IL17B).

Mini Samples Mouse Interleukin 17B (IL17B) ELISA Kit

4-MEB700Mu
  • EUR 6688.80
  • EUR 3534.00
  • EUR 879.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mini Samples Mouse Interleukin 17B (IL17B) in samples from n/a with no significant corss-reactivity with analogues from other species.

IL17B Human, Interleukin-17B Human Recombinant Protein, Sf9

PROTQ9UHF5-2 Regular: 5ug
EUR 380.4
Description: IL17B Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 169 amino acids (21-180a.a.) and having a molecular mass of 19.2kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). IL17B is expressed with a 6 amino acid His-tag at C-Terminus and purified by proprietary chromatographic techniques.

IL17B Human, Interleukin-17B Human Recombinant Protein, His Tag

PROTQ9UHF5 Regular: 25ug
EUR 380.4
Description: IL17B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 185 amino acids (21-180) and having a molecular mass of 20kDa.;IL17B is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Human Interleukin 17B,IL-17B ELISA Kit

201-12-2166 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

IL-17B Interleukin 17B Human Recombinant Protein

PROTQ9UHF5-1 Regular: 25ug
EUR 380.4
Description: Interleukin-17B Human Recombinant produced in E.Coli is a homodimeric, non-disulfide-linked polypeptide chain containing a total of 322 amino acids (2 chains of 161aa) and having a molecular mass of 36.5kDa. The IL-17B is purified by proprietary chromatographic techniques.

Human Interleukin 17B(IL-17B)ELISA Kit

QY-E04321 96T
EUR 433.2

Rat Interleukin 17B(IL-17B)ELISA Kit

QY-E10619 96T
EUR 433.2

Mouse Interleukin 17B(IL-17B)ELISA Kit

QY-E20839 96T
EUR 433.2

Recombinant Human Interleukin-17B/IL-17B (C-Fc)

CB78-10ug 10ug
EUR 169.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-17B/IL-17B (C-Fc)

CB78-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-17B/IL-17B (C-Fc)

CB78-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-17B/IL-17B (C-Fc)

CB78-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human IL17B/ IL-17B Protein, Untagged, E.coli-100ug

QP10305-ec-100ug 100ug
EUR 1185.6

Recombinant Human IL17B/ IL-17B Protein, Untagged, E.coli-250ug

QP10305-ec-250ug 250ug
EUR 2077.2

Recombinant Human IL17B/ IL-17B Protein, Untagged, E.coli-25ug

QP10305-ec-25ug 25ug
EUR 348

Recombinant Human IL17B/ IL-17B Protein, Untagged, E.coli-5ug

QP10305-ec-5ug 5ug
EUR 184.8

Active Interleukin 10 (IL10)

4-APA056Hu61
  • EUR 1019.94
  • EUR 397.20
  • EUR 3494.78
  • EUR 1244.93
  • EUR 2369.86
  • EUR 758.40
  • EUR 8556.96
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 10 expressed in: 293F cell

Active Interleukin 11 (IL11)

4-APA057Hu01
  • EUR 1087.68
  • EUR 415.20
  • EUR 3748.80
  • EUR 1329.60
  • EUR 2539.20
  • EUR 804.00
  • EUR 9192.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 11 expressed in: E.coli

Active Interleukin 13 (IL13)

4-APA060Ra01
  • EUR 1048.97
  • EUR 404.40
  • EUR 3603.65
  • EUR 1281.22
  • EUR 2442.43
  • EUR 777.60
  • EUR 8829.12
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Active Interleukin 13 (IL13) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 15 (IL15)

4-APA061Hu01
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • EUR 1464.00
  • EUR 2808.00
  • EUR 876.00
  • EUR 10200.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 15 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 16 (IL16)

4-APA062Hu01
  • EUR 1087.68
  • EUR 415.20
  • EUR 3748.80
  • EUR 1329.60
  • EUR 2539.20
  • EUR 804.00
  • EUR 9192.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 16 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 17 (IL17)

4-APA063Hu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 17 expressed in: E.coli

Active Interleukin 18 (IL18)

4-APA064Hu01
  • EUR 797.38
  • EUR 337.20
  • EUR 2660.16
  • EUR 966.72
  • EUR 1813.44
  • EUR 609.60
  • EUR 6470.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 18 (IL18)

4-APA064Mu01
  • EUR 689.86
  • EUR 308.40
  • EUR 2256.96
  • EUR 832.32
  • EUR 1544.64
  • EUR 537.60
  • EUR 5462.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 2 (IL2)

4-APA073Hu61
  • EUR 872.64
  • EUR 357.60
  • EUR 2942.40
  • EUR 1060.80
  • EUR 2001.60
  • EUR 660.00
  • EUR 7176.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 2 expressed in: 293F cell

Active Interleukin 2 (IL2)

4-APA073Mu61
  • EUR 808.13
  • EUR 339.60
  • EUR 2700.48
  • EUR 980.16
  • EUR 1840.32
  • EUR 616.80
  • EUR 6571.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 2 expressed in: 293F cell

Active Interleukin 4 (IL4)

4-APA077Hu01
  • EUR 798.46
  • EUR 337.20
  • EUR 2664.19
  • EUR 968.06
  • EUR 1816.13
  • EUR 609.60
  • EUR 6480.48
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 4 expressed in: E.coli

Active Interleukin 4 (IL4)

4-APA077Hu61
  • EUR 939.30
  • EUR 375.60
  • EUR 3192.38
  • EUR 1144.13
  • EUR 2168.26
  • EUR 704.40
  • EUR 7800.96
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 4 expressed in: 293F cell

Active Interleukin 4 (IL4)

4-APA077Mu01
  • EUR 781.25
  • EUR 332.40
  • EUR 2599.68
  • EUR 946.56
  • EUR 1773.12
  • EUR 598.80
  • EUR 6319.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 4 expressed in: E.coli

We showed that Human p.R281Q gp130 associated with selective loss IL – 11 signals without affecting the IL – 6 IL -27, OSM, LIF, CT1, CLC, and CNTF signal. In mice Il6st p.R279Q reduce the size of garbage and cause synostosis facial and dental abnormalities. Effects on IL – 11 signaling induced by gp130 variants showed incomplete penetrance but phenocopies aspect IL 11 RA deficiencies in the human and mice. Our data indicate that genetically in pleiotropic cytokine receptor variants may have a very selective flaw.

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Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits, Uncategorized, Vector & Virus, Western Blot

Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.

Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.

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