influenza virus is most commonly Human and the pathogen responsible for causing seasonal extensive morbidity and mortality. To investigate the immunological factors associated with severe influenza infection, the immune response in infected mice with nonlethal (LD0) doses of A / PR / 8/34 (H1N1) influenza virus compared with those of mice infected with a dose of off (LD100) of the virus. Virus titers and activation of the retinoic acid-induced gene (RIG) -I-like receptor signaling pathways similar in mice infected with LD0 and LD100 at 2 days post-infection;

However, mice infected with LD100 exhibited a greater abundance of cytokines and cytokine profile that is more diverse. LD100 infection induced the expression of the following factors: Interleukin ( IL s), IL -4, IL -7, IL -10, IL – 11 , IL -12p40, IL -13 and IL < / em> -15; inflammatory chemokines, C-C motif chemokine ligand (CCL) 2, CCL3 / 4, CCL12, CCL17, CCL19; and lung injury associated cytokines, leptin, leukemia inhibitory factor, macrophage colony stimulating factor, pentraxin (PTX) 2 and PTX3, WNT1-induced-signaling pathway protein 1, matrix metallopeptidase (MMP) -2, MMP-3, proprotein convertase Subtilisin / Kexin type of 9 and T cell immunoglobulin and mucin domain.

Switching in polarization of M1 to M2 macrophages was evidenced by an increase in markers M2, including arginase-1 (arg1) and early growth response protein 2 (Egr2), in the lungs of mice infected with the LD100. Since the IL -12 and interferon-γ is the main T helper (Th) 1 cytokine, increased expression of interferon regulatory factor 4, IL -4, IL -10 and IL -13 promoted the differentiation of naive CD4transcriptomic characterization of related cultural change in murine and precision-cut slices of human tissue.

Our knowledge of the pathological mechanisms underlying complex organ fibrosis mainly derived from animal studies. However, the relevance of animal models for Human disease is limited; Therefore, ex vivo model of Human tissue slices precision-cut (PCT) may become an indispensable tool in the study of fibrosis and the development of medicine by bridging of animals Human translational gap. This study, presented as a two-part, providing a comprehensive characterization of the dynamic changes in the PCT during transcription by RNA sequencing culture. Part I investigate the differences in the cultural response induced in murine and Human PCT comes from a healthy liver, kidneys and intestines.

Part II depicts the molecular processes in cultured Human PCT generated from the diseased liver, kidney and ileum. We show that culture is associated with extensive transcriptional changes and PCT universal influence on organ and two species with triggers an inflammatory response and fibrosis associated extracellular matrix (ECM) remodeling. All PCT together with mRNA upregulation of IL – 11 and ECM-degrading enzyme matrix metalloproteinase-3 and MMP10.

Active Interleukin 11 (IL11)
MBS2097260-01mg	MyBiosource	0.1mg	EUR 885

Active Interleukin 11 (IL11)
MBS2097260-02mg	MyBiosource	0.2mg	EUR 1090

Active Interleukin 11 (IL11)
MBS2097260-05mg	MyBiosource	0.5mg	EUR 2130

Active Interleukin 11 (IL11)
MBS2122266-001mg	MyBiosource	0.01mg	EUR 250

Active Interleukin 11 (IL11)
MBS2122266-005mg	MyBiosource	0.05mg	EUR 530

Active Interleukin 11 (IL11)
MBS2122266-01mg	MyBiosource	0.1mg	EUR 810

Active Interleukin 11 (IL11)
MBS2122266-02mg	MyBiosource	0.2mg	EUR 1005

Active Interleukin 11 (IL11)
MBS2122266-05mg	MyBiosource	0.5mg	EUR 1950

Active Interleukin 11 (IL11)
RPU59219-100ug	Biomatik Corporation	100ug	EUR 1084.1

Active Interleukin 11 (IL11)
RPU59219-1mg	Biomatik Corporation	1mg	EUR 4802.9

Active Interleukin 11 (IL11)
RPU59219-50ug	Biomatik Corporation	50ug	EUR 722.5

Active Interleukin 11 (IL11)
RPU54855-100ug	Biomatik Corporation	100ug	EUR 1108.8

Active Interleukin 11 (IL11)
RPU54855-1mg	Biomatik Corporation	1mg	EUR 4914

Active Interleukin 11 (IL11)
RPU54855-50ug	Biomatik Corporation	50ug	EUR 891

Human Interleukin 11 (IL11) Protein (Active)
20-abx655712	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	10 ug 50 ug 100 ug 200 ug 1 mg

Human Interleukin 11 (IL11) Protein (Active)
abx655712-50g	Abbexa	50 µg	EUR 650

Human Interleukin 11 (IL11) Protein (Active)
20-abx651374	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	10 ug 50 ug 100 ug 200 ug 1 mg

Human Interleukin 11 (IL11) Protein (Active)
abx651374-5mg	Abbexa	5 mg	EUR 1062.5

Recombinant Human Interleukin-11 protein (IL11) (Active)
CSB-AP001801HU	Cusabio	8263 mg	Ask for price

Recombinant Human Interleukin-11 protein (IL11) (Active)
CSB-AP001801HU-100ug	Cusabio	100ug	Ask for price
Description: 22-199aa

Recombinant Human Interleukin-11 protein (IL11) (Active)
CSB-AP001801HU-10ug	Cusabio	10ug	Ask for price
Description: 22-199aa

Recombinant Human Interleukin-11 protein (IL11) (Active)
CSB-AP001801HU-500ug	Cusabio	500ug	Ask for price
Description: 22-199aa

Recombinant Mouse Interleukin-11 protein (Il11) (Active)
CSB-AP003361MO	Cusabio	8301 mg	Ask for price

Recombinant Mouse Interleukin-11 protein (Il11) (Active)
CSB-AP003361MO-100ug	Cusabio	100ug	Ask for price
Description: 22-199aa

Recombinant Mouse Interleukin-11 protein (Il11) (Active)
CSB-AP003361MO-10ug	Cusabio	10ug	Ask for price
Description: 22-199aa

Recombinant Mouse Interleukin-11 protein (Il11) (Active)
CSB-AP003361MO-500ug	Cusabio	500ug	Ask for price
Description: 22-199aa

Recombinant Human Interleukin-11 protein(IL11) (Active)
AP73445	SAB	1mg	EUR 6829

Recombinant Mouse Interleukin-11 protein(Il11) (Active)
AP73446	SAB	1mg	EUR 6829

Recombinant Human Interleukin-11 protein (IL11) (Active)
MBS969298-001mg	MyBiosource	0.01mg	EUR 355

Recombinant Human Interleukin-11 protein (IL11) (Active)
MBS969298-01mg	MyBiosource	0.1mg	EUR 1590

Recombinant Human Interleukin-11 protein (IL11) (Active)
MBS969298-05mg	MyBiosource	0.5mg	EUR 3395

Recombinant Human Interleukin-11 protein (IL11) (Active)
MBS969298-5x05mg	MyBiosource	5x0.5mg	EUR 15240

Recombinant Mouse Interleukin-11 protein (Il11) (Active)
MBS969454-001mg	MyBiosource	0.01mg	EUR 355

Recombinant Mouse Interleukin-11 protein (Il11) (Active)
MBS969454-01mg	MyBiosource	0.1mg	EUR 1590

Recombinant Mouse Interleukin-11 protein (Il11) (Active)
MBS969454-05mg	MyBiosource	0.5mg	EUR 3395

Recombinant Mouse Interleukin-11 protein (Il11) (Active)
MBS969454-5x05mg	MyBiosource	5x0.5mg	EUR 15240

Active Interleukin 10 (IL10)
APA056Bo61	Cloud-Clone	10ug	EUR 368

Active Interleukin 10 (IL10)
APA056Ca61	Cloud-Clone	10ug	EUR 328

Active Interleukin 10 (IL10)
APA056Eq61	Cloud-Clone	10ug	EUR 380

Active Interleukin 10 (IL10)
APA056Ga61	Cloud-Clone	10ug	EUR 319

Active Interleukin 10 (IL10)
APA056Hu61	Cloud-Clone	10ug	EUR 335

Active Interleukin 10 (IL10)
4-APA056Hu61	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	10ug 50ug 100 ug 200 ug 500 ug 1 mg 5 mg
Description: Recombinant Human Interleukin 10 expressed in: 293F cell

Active Interleukin 10 (IL10)
APA056Mu61	Cloud-Clone	10ug	EUR 324

Active Interleukin 10 (IL10)
APA056Ra01	Cloud-Clone	10ug	EUR 350

Active Interleukin 10 (IL10)
APA056Ra61	Cloud-Clone	10ug	EUR 251

Active Interleukin 10 (IL10)
APA056Rb61	Cloud-Clone	10ug	EUR 331

Active Interleukin 13 (IL13)
APA060Hu01	Cloud-Clone	10ug	EUR 317

Active Interleukin 13 (IL13)
APA060Ra01	Cloud-Clone	10ug	EUR 211

Active Interleukin 13 (IL13)
4-APA060Ra01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	10ug 50ug 100 ug 200 ug 500 ug 1 mg 5 mg
Description: Recombinant Rat Active Interleukin 13 (IL13) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 15 (IL15)
APA061Hu01	Cloud-Clone	10ug	EUR 400

Active Interleukin 15 (IL15)
4-APA061Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	10ug 50ug 100 ug 200 ug 500 ug 1 mg 5 mg
Description: Recombinant Human Interleukin 15 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 16 (IL16)
APA062Hu01	Cloud-Clone	10ug	EUR 360

Active Interleukin 16 (IL16)
4-APA062Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	10ug 50ug 100 ug 200 ug 500 ug 1 mg 5 mg
Description: Recombinant Human Interleukin 16 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 17 (IL17)
APA063Hu01	Cloud-Clone	10ug	EUR 167

Active Interleukin 17 (IL17)
4-APA063Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	10ug 50ug 100 ug 200 ug 500 ug 1 mg 5 mg
Description: Recombinant Human Interleukin 17 expressed in: E.coli

Active Interleukin 17 (IL17)
APA063Mu61	Cloud-Clone	10ug	EUR 272

Active Interleukin 17 (IL17)
APA063Po61	Cloud-Clone	10ug	EUR 280

Active Interleukin 18 (IL18)
APA064Hu01	Cloud-Clone	10ug	EUR 239

Active Interleukin 18 (IL18)
4-APA064Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	10ug 50ug 100 ug 200 ug 500 ug 1 mg 5 mg
Description: Recombinant Human Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 18 (IL18)
APA064Mu01	Cloud-Clone	10ug	EUR 233

Active Interleukin 18 (IL18)
4-APA064Mu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	10ug 50ug 100 ug 200 ug 500 ug 1 mg 5 mg
Description: Recombinant Mouse Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 19 (IL19)
APB190Hu61	Cloud-Clone	10ug	EUR 350

Active Interleukin 19 (IL19)
APB190Mu61	Cloud-Clone	10ug	EUR 380

Active Interleukin 19 (IL19)
APB190Ra61	Cloud-Clone	10ug	EUR 372

Active Interleukin 21 (IL21)
APB688Hu01	Cloud-Clone	10ug	EUR 250

Active Interleukin 21 (IL21)
4-APB688Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 mg 10ug 50ug 100 ug 200 ug 500 ug 1 mg
Description: Recombinant Human Interleukin 21 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 21 (IL21)
APB688Hu61	Cloud-Clone	10ug	EUR 300

Active Interleukin 21 (IL21)
APB688Ra61	Cloud-Clone	10ug	EUR 269

Active Interleukin 25 (IL25)
APB694Hu01	Cloud-Clone	10ug	EUR 240

Active Interleukin 25 (IL25)
4-APB694Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 mg 10ug 50ug 100 ug 200 ug 500 ug 1 mg
Description: Recombinant Human Interleukin 25 expressed in: E.coli

Active Interleukin 25 (IL25)
APB694Hu61	Cloud-Clone	10ug	EUR 280

Active Interleukin 25 (IL25)
APB694Ra61	Cloud-Clone	10ug	EUR 272

Active Interleukin 33 (IL33)
APB980Hu01	Cloud-Clone	10ug	EUR 328

Active Interleukin 33 (IL33)
4-APB980Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 mg 10ug 50ug 100 ug 200 ug 500 ug 1 mg
Description: Recombinant Human Interleukin 33 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 34 (IL34)
APC007Hu01	Cloud-Clone	10ug	EUR 252

Active Interleukin 34 (IL34)
4-APC007Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 mg 10ug 50ug 100 ug 200 ug 500 ug 1 mg
Description: Recombinant Human Active Interleukin 34 (IL34) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 34 (IL34)
APC007Hu61	Cloud-Clone	10ug	EUR 316

Active Interleukin 34 (IL34)
APC007Mu01	Cloud-Clone	10ug	EUR 326

Active Interleukin 34 (IL34)
APC007Mu61	Cloud-Clone	10ug	EUR 320

Active Interleukin 35 (IL35)
APC008Hu01	Cloud-Clone	10ug	EUR 200

Active Interleukin 35 (IL35)
4-APC008Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 mg 10ug 50ug 100 ug 200 ug 500 ug 1 mg
Description: Recombinant Human Interleukin 35 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 29 (IL29)
APC029Hu01	Cloud-Clone	10ug	EUR 211

Active Interleukin 29 (IL29)
4-APC029Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 mg 10ug 50ug 100 ug 200 ug 500 ug 1 mg
Description: Recombinant Human Interleukin 29 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 29 (IL29)
APC029Ra61	Cloud-Clone	10ug	EUR 280

Active Interleukin 22 (IL22)
APC032Hu01	Cloud-Clone	10ug	EUR 324

Active Interleukin 22 (IL22)
4-APC032Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 mg 10ug 50ug 100 ug 200 ug 500 ug 1 mg
Description: Recombinant Human Interleukin 22 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 22 (IL22)
APC032Hu61	Cloud-Clone	10ug	EUR 324

Active Interleukin 22 (IL22)
APC032Mu61	Cloud-Clone	10ug	EUR 276

Active Interleukin 20 (IL20)
APC058Hu01	Cloud-Clone	10ug	EUR 219

Active Interleukin 20 (IL20)
4-APC058Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 mg 10ug 50ug 100 ug 200 ug 500 ug 1 mg
Description: Recombinant Human Interleukin 20 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 20 (IL20)
APC058Mu61	Cloud-Clone	10ug	EUR 371

Active Interleukin 24 (IL24)
APC064Hu01	Cloud-Clone	10ug	EUR 211

Active Interleukin 24 (IL24)
4-APC064Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 mg 10ug 50ug 100 ug 200 ug 500 ug 1 mg
Description: Recombinant Human Interleukin 24 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 23 (IL23)
APX262Mu61	Cloud-Clone	10ug	EUR 340

Active Interleukin 13 (IL13)
MBS2105067-001mg	MyBiosource	0.01mg	EUR 190

Active Interleukin 13 (IL13)
MBS2105067-005mg	MyBiosource	0.05mg	EUR 355

Active Interleukin 13 (IL13)
MBS2105067-01mg	MyBiosource	0.1mg	EUR 540

Active Interleukin 13 (IL13)
MBS2105067-02mg	MyBiosource	0.2mg	EUR 660

Active Interleukin 13 (IL13)
MBS2105067-05mg	MyBiosource	0.5mg	EUR 1270

Active Interleukin 18 (IL18)
MBS2105068-001mg	MyBiosource	0.01mg	EUR 205

Active Interleukin 18 (IL18)
MBS2105068-005mg	MyBiosource	0.05mg	EUR 400

Active Interleukin 18 (IL18)
MBS2105068-01mg	MyBiosource	0.1mg	EUR 610

Active Interleukin 18 (IL18)
MBS2105068-02mg	MyBiosource	0.2mg	EUR 745

Active Interleukin 18 (IL18)
MBS2105068-05mg	MyBiosource	0.5mg	EUR 1430

Active Interleukin 21 (IL21)
MBS2105147-001mg	MyBiosource	0.01mg	EUR 215

Active Interleukin 21 (IL21)
MBS2105147-005mg	MyBiosource	0.05mg	EUR 415

Active Interleukin 21 (IL21)
MBS2105147-01mg	MyBiosource	0.1mg	EUR 630

Active Interleukin 21 (IL21)
MBS2105147-02mg	MyBiosource	0.2mg	EUR 775

Active Interleukin 21 (IL21)
MBS2105147-05mg	MyBiosource	0.5mg	EUR 1490

Active Interleukin 33 (IL33)
MBS2105157-001mg	MyBiosource	0.01mg	EUR 250

Active Interleukin 33 (IL33)
MBS2105157-005mg	MyBiosource	0.05mg	EUR 525

Active Interleukin 33 (IL33)
MBS2105157-01mg	MyBiosource	0.1mg	EUR 810

Active Interleukin 33 (IL33)
MBS2105157-02mg	MyBiosource	0.2mg	EUR 1005

Active Interleukin 33 (IL33)
MBS2105157-05mg	MyBiosource	0.5mg	EUR 1945

Active Interleukin 34 (IL34)
MBS2105158-001mg	MyBiosource	0.01mg	EUR 215

Active Interleukin 34 (IL34)
MBS2105158-005mg	MyBiosource	0.05mg	EUR 420

Active Interleukin 34 (IL34)
MBS2105158-01mg	MyBiosource	0.1mg	EUR 635

Active Interleukin 34 (IL34)
MBS2105158-02mg	MyBiosource	0.2mg	EUR 780

Active Interleukin 34 (IL34)
MBS2105158-05mg	MyBiosource	0.5mg	EUR 1505

Active Interleukin 29 (IL29)
MBS2105160-001mg	MyBiosource	0.01mg	EUR 190

Active Interleukin 29 (IL29)
MBS2105160-005mg	MyBiosource	0.05mg	EUR 355

Active Interleukin 29 (IL29)
MBS2105160-01mg	MyBiosource	0.1mg	EUR 540

Active Interleukin 29 (IL29)
MBS2105160-02mg	MyBiosource	0.2mg	EUR 660

Active Interleukin 29 (IL29)
MBS2105160-05mg	MyBiosource	0.5mg	EUR 1270

slice preparation and active cultures various channels in all PCT, especially those involved in inflammation ( IL -6, IL -8 and signaling HMGB1) and tissue remodeling (osteoarthritis pathways and integrin signaling). Although the effect of converging cultures, PCT featuring species -, – organ and specific pathological differences in the regulation of gene and the canonical pathway. The underlying pathology in the Human PCT ever sick and influence biological processes such as the release of cytokines.