Deoxynivalenol (DON) is an unavoidable contaminants in the Human of food, fodder and agricultural products. Growth retardation in children caused by pollution comprehensive DON has become a global problem that can not be ignored. Previous research has shown that DON causes stunting in children with bowel dysfunction, insulin-like growth factor-1 (IGF-1) axis disruption and peptide YY (PYY). Galanin-like peptide (GALP) is a growth regulator that is important, but its role in DON-induced growth retardation is unclear.
In this study, we report the important role GALP for DON-induced growth inhibition in rat pituitary tumor cell line GH3. DON was found to increase the expression of GALP through hypomethylationin promoter region of GALP gene and upregulate the expression of proinflammatory factors, while downregulate the expression of growth hormone (GH). Furthermore, GALP promoted excessive proinflammatory cytokines, including TNF-α, IL -1β, IL – 11 and IL -6, and will decrease cell viability and cell proliferation, while the inhibitory effect of GALP is the opposite.
GALP expression and insulin-like growth factor binding protein acidic labile subunit (IGFALS) showed the opposite trend, which is the reason the potential regulation of cell proliferation by GALP. Additionally, GALP has anti-apoptotic effects, which can eliminate the inflammatory damage to the cells, thereby contributing to the inhibition of cell growth.
These findings provide new mechanistic insight into the toxicity of DON-induced growth retardation and suggest the therapeutic potential GALP on DON-related diseases.
Epigenetic upregulation of galanin-like peptide mediates deoxynivalenol induced-growth inhibition in pituitary cells
The immunoregulatory and neuroprotective effects of Human of adipose derived stem cells that express the IL – 11 and IL in the experimental -13 autoimmune encephalomyelitis mice
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) characterized by incomplete endogenous remyelination in the chronic phase. The shift of cytokine balance between pro and anti-inflammatory is one important marker in the patho gene is from MS. This study aimed to evaluate the effect of Human of adipose-derived stem cells (hADSCs) expressing interleukin 11 and interleukin 13 ( IL – 11 , 13-hADSCs) in experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
12 days after immunization C57BL / 6 female mice with MOG35-55 and the early appearance of clinical symptoms, IL – < em> 11 , 13-hADSCs injected via the tail vein into mice EAE. Then, the mice were sacrificed at 30 days post-immunization (DPI) and the spinal cord of the experimental group were extracted for histopathological and real-time RT-PCR results showed that clinical scores studies.
The and infiltration of mononuclear cells into the spinal cords of EAE mice was significantly reduced in mice treated with IL – 11 , 13-hADSCs. Similarly, remyelination and oligodendro gene was significantly improved in the treatment group mentioned. Real-time results show that the cytokine pro / anti-inflammatory gene expression overturned in the IL – 11 , 13-hADSCs treatment group compared to those without EAE untreated group.
Human Interleukin 20 (IL20) Protein (Active)
20-abx651390
Abbexa
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50 ug
100 ug
200 ug
1 mg
Human Interleukin 20 (IL20) Protein (Active)
abx651390-5mg
Abbexa
5 mg
EUR 687.5
Recombinant Human Interleukin-20 protein(IL20) (Active)
AP73473
SAB
1mg
EUR 6829
Recombinant Human Interleukin-20 protein (IL20) (Active)
CSB-AP001871HU
Cusabio
8269 mg
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Recombinant Human Interleukin-20 protein (IL20) (Active)
CSB-AP001871HU-100ug
Cusabio
100ug
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Description: 25-176aa
Recombinant Human Interleukin-20 protein (IL20) (Active)
CSB-AP001871HU-10ug
Cusabio
10ug
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Description: 25-176aa
Recombinant Human Interleukin-20 protein (IL20) (Active)
CSB-AP001871HU-500ug
Cusabio
500ug
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Description: 25-176aa
Recombinant Human Interleukin-20 protein (IL20) (Active)
MBS969305-001mg
MyBiosource
0.01mg
EUR 355
Recombinant Human Interleukin-20 protein (IL20) (Active)
MBS969305-01mg
MyBiosource
0.1mg
EUR 1590
Recombinant Human Interleukin-20 protein (IL20) (Active)
MBS969305-05mg
MyBiosource
0.5mg
EUR 3395
Recombinant Human Interleukin-20 protein (IL20) (Active)
MBS969305-5x05mg
MyBiosource
5x0.5mg
EUR 15240
Active Interleukin 10 (IL10)
APA056Bo61
Cloud-Clone
10ug
EUR 368
Active Interleukin 10 (IL10)
APA056Ca61
Cloud-Clone
10ug
EUR 328
Active Interleukin 10 (IL10)
APA056Eq61
Cloud-Clone
10ug
EUR 380
Active Interleukin 10 (IL10)
APA056Ga61
Cloud-Clone
10ug
EUR 319
Active Interleukin 10 (IL10)
APA056Hu61
Cloud-Clone
10ug
EUR 335
Active Interleukin 10 (IL10)
4-APA056Hu61
Cloud-Clone
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1 mg
5 mg
Description: Recombinant Human Interleukin 10 expressed in: 293F cell
Active Interleukin 10 (IL10)
APA056Mu61
Cloud-Clone
10ug
EUR 324
Active Interleukin 10 (IL10)
APA056Ra01
Cloud-Clone
10ug
EUR 350
Active Interleukin 10 (IL10)
APA056Ra61
Cloud-Clone
10ug
EUR 251
Active Interleukin 10 (IL10)
APA056Rb61
Cloud-Clone
10ug
EUR 331
Active Interleukin 11 (IL11)
APA057Hu01
Cloud-Clone
10ug
EUR 360
Active Interleukin 11 (IL11)
4-APA057Hu01
Cloud-Clone
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50ug
100 ug
200 ug
500 ug
1 mg
5 mg
Description: Recombinant Human Interleukin 11 expressed in: E.coli
Active Interleukin 11 (IL11)
APA057Hu61
Cloud-Clone
10ug
EUR 328
Active Interleukin 11 (IL11)
APA057Hu62
Cloud-Clone
10ug
EUR 332
Active Interleukin 13 (IL13)
APA060Hu01
Cloud-Clone
10ug
EUR 317
Active Interleukin 13 (IL13)
APA060Ra01
Cloud-Clone
10ug
EUR 211
Active Interleukin 13 (IL13)
4-APA060Ra01
Cloud-Clone
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500 ug
1 mg
5 mg
Description: Recombinant Rat Active Interleukin 13 (IL13) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 15 (IL15)
APA061Hu01
Cloud-Clone
10ug
EUR 400
Active Interleukin 15 (IL15)
4-APA061Hu01
Cloud-Clone
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50ug
100 ug
200 ug
500 ug
1 mg
5 mg
Description: Recombinant Human Interleukin 15 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 16 (IL16)
APA062Hu01
Cloud-Clone
10ug
EUR 360
Active Interleukin 16 (IL16)
4-APA062Hu01
Cloud-Clone
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50ug
100 ug
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500 ug
1 mg
5 mg
Description: Recombinant Human Interleukin 16 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 17 (IL17)
APA063Hu01
Cloud-Clone
10ug
EUR 167
Active Interleukin 17 (IL17)
4-APA063Hu01
Cloud-Clone
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50ug
100 ug
200 ug
500 ug
1 mg
5 mg
Description: Recombinant Human Interleukin 17 expressed in: E.coli
Active Interleukin 17 (IL17)
APA063Mu61
Cloud-Clone
10ug
EUR 272
Active Interleukin 17 (IL17)
APA063Po61
Cloud-Clone
10ug
EUR 280
Active Interleukin 18 (IL18)
APA064Hu01
Cloud-Clone
10ug
EUR 239
Active Interleukin 18 (IL18)
4-APA064Hu01
Cloud-Clone
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500 ug
1 mg
5 mg
Description: Recombinant Human Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 18 (IL18)
APA064Mu01
Cloud-Clone
10ug
EUR 233
Active Interleukin 18 (IL18)
4-APA064Mu01
Cloud-Clone
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10ug
50ug
100 ug
200 ug
500 ug
1 mg
5 mg
Description: Recombinant Mouse Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 23 (IL23)
APX262Mu61
Cloud-Clone
10ug
EUR 340
Active Interleukin 29 (IL29)
APC029Ra61
Cloud-Clone
10ug
EUR 280
Active Interleukin 22 (IL22)
APC032Hu01
Cloud-Clone
10ug
EUR 324
Active Interleukin 22 (IL22)
4-APC032Hu01
Cloud-Clone
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5 mg
10ug
50ug
100 ug
200 ug
500 ug
1 mg
Description: Recombinant Human Interleukin 22 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 22 (IL22)
APC032Hu61
Cloud-Clone
10ug
EUR 324
Active Interleukin 22 (IL22)
APC032Mu61
Cloud-Clone
10ug
EUR 276
Active Interleukin 24 (IL24)
APC064Hu01
Cloud-Clone
10ug
EUR 211
Active Interleukin 24 (IL24)
4-APC064Hu01
Cloud-Clone
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5 mg
10ug
50ug
100 ug
200 ug
500 ug
1 mg
Description: Recombinant Human Interleukin 24 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 19 (IL19)
APB190Hu61
Cloud-Clone
10ug
EUR 350
Active Interleukin 19 (IL19)
APB190Mu61
Cloud-Clone
10ug
EUR 380
Active Interleukin 19 (IL19)
APB190Ra61
Cloud-Clone
10ug
EUR 372
Active Interleukin 21 (IL21)
APB688Hu01
Cloud-Clone
10ug
EUR 250
Active Interleukin 21 (IL21)
4-APB688Hu01
Cloud-Clone
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5 mg
10ug
50ug
100 ug
200 ug
500 ug
1 mg
Description: Recombinant Human Interleukin 21 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 21 (IL21)
APB688Hu61
Cloud-Clone
10ug
EUR 300
Active Interleukin 21 (IL21)
APB688Ra61
Cloud-Clone
10ug
EUR 269
Active Interleukin 25 (IL25)
APB694Hu01
Cloud-Clone
10ug
EUR 240
Active Interleukin 25 (IL25)
4-APB694Hu01
Cloud-Clone
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5 mg
10ug
50ug
100 ug
200 ug
500 ug
1 mg
Description: Recombinant Human Interleukin 25 expressed in: E.coli
Active Interleukin 25 (IL25)
APB694Hu61
Cloud-Clone
10ug
EUR 280
Active Interleukin 25 (IL25)
APB694Ra61
Cloud-Clone
10ug
EUR 272
Active Interleukin 33 (IL33)
APB980Hu01
Cloud-Clone
10ug
EUR 328
Active Interleukin 33 (IL33)
4-APB980Hu01
Cloud-Clone
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5 mg
10ug
50ug
100 ug
200 ug
500 ug
1 mg
Description: Recombinant Human Interleukin 33 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 34 (IL34)
APC007Hu01
Cloud-Clone
10ug
EUR 252
Active Interleukin 34 (IL34)
4-APC007Hu01
Cloud-Clone
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5 mg
10ug
50ug
100 ug
200 ug
500 ug
1 mg
Description: Recombinant Human Active Interleukin 34 (IL34) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 34 (IL34)
APC007Hu61
Cloud-Clone
10ug
EUR 316
Active Interleukin 34 (IL34)
APC007Mu01
Cloud-Clone
10ug
EUR 326
Active Interleukin 34 (IL34)
APC007Mu61
Cloud-Clone
10ug
EUR 320
Active Interleukin 35 (IL35)
APC008Hu01
Cloud-Clone
10ug
EUR 200
Active Interleukin 35 (IL35)
4-APC008Hu01
Cloud-Clone
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5 mg
10ug
50ug
100 ug
200 ug
500 ug
1 mg
Description: Recombinant Human Interleukin 35 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 29 (IL29)
APC029Hu01
Cloud-Clone
10ug
EUR 211
Active Interleukin 29 (IL29)
4-APC029Hu01
Cloud-Clone
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5 mg
10ug
50ug
100 ug
200 ug
500 ug
1 mg
Description: Recombinant Human Interleukin 29 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Interleukin 21 (IL21)
MBS2105147-001mg
MyBiosource
0.01mg
EUR 215
Active Interleukin 21 (IL21)
MBS2105147-005mg
MyBiosource
0.05mg
EUR 415
Active Interleukin 21 (IL21)
MBS2105147-01mg
MyBiosource
0.1mg
EUR 630
Active Interleukin 21 (IL21)
MBS2105147-02mg
MyBiosource
0.2mg
EUR 775
Active Interleukin 21 (IL21)
MBS2105147-05mg
MyBiosource
0.5mg
EUR 1490
Active Interleukin 33 (IL33)
MBS2105157-001mg
MyBiosource
0.01mg
EUR 250
Active Interleukin 33 (IL33)
MBS2105157-005mg
MyBiosource
0.05mg
EUR 525
Active Interleukin 33 (IL33)
MBS2105157-01mg
MyBiosource
0.1mg
EUR 810
Active Interleukin 33 (IL33)
MBS2105157-02mg
MyBiosource
0.2mg
EUR 1005
Active Interleukin 33 (IL33)
MBS2105157-05mg
MyBiosource
0.5mg
EUR 1945
Active Interleukin 34 (IL34)
MBS2105158-001mg
MyBiosource
0.01mg
EUR 215
Active Interleukin 34 (IL34)
MBS2105158-005mg
MyBiosource
0.05mg
EUR 420
Active Interleukin 34 (IL34)
MBS2105158-01mg
MyBiosource
0.1mg
EUR 635
Active Interleukin 34 (IL34)
MBS2105158-02mg
MyBiosource
0.2mg
EUR 780
Active Interleukin 34 (IL34)
MBS2105158-05mg
MyBiosource
0.5mg
EUR 1505
Active Interleukin 29 (IL29)
MBS2105160-001mg
MyBiosource
0.01mg
EUR 190
Active Interleukin 29 (IL29)
MBS2105160-005mg
MyBiosource
0.05mg
EUR 355
Active Interleukin 29 (IL29)
MBS2105160-01mg
MyBiosource
0.1mg
EUR 540
Active Interleukin 29 (IL29)
MBS2105160-02mg
MyBiosource
0.2mg
EUR 660
Active Interleukin 29 (IL29)
MBS2105160-05mg
MyBiosource
0.5mg
EUR 1270
Active Interleukin 22 (IL22)
MBS2105162-001mg
MyBiosource
0.01mg
EUR 245
Active Interleukin 22 (IL22)
MBS2105162-005mg
MyBiosource
0.05mg
EUR 520
Active Interleukin 22 (IL22)
MBS2105162-01mg
MyBiosource
0.1mg
EUR 800
Active Interleukin 22 (IL22)
MBS2105162-02mg
MyBiosource
0.2mg
EUR 990
Active Interleukin 22 (IL22)
MBS2105162-05mg
MyBiosource
0.5mg
EUR 1925
Active Interleukin 10 (IL10)
MBS2122264-001mg
MyBiosource
0.01mg
EUR 245
Active Interleukin 10 (IL10)
MBS2122264-005mg
MyBiosource
0.05mg
EUR 520
Active Interleukin 10 (IL10)
MBS2122264-01mg
MyBiosource
0.1mg
EUR 800
Active Interleukin 10 (IL10)
MBS2122264-02mg
MyBiosource
0.2mg
EUR 990
Active Interleukin 10 (IL10)
MBS2122264-05mg
MyBiosource
0.5mg
EUR 1925
Active Interleukin 10 (IL10)
MBS2122265-001mg
MyBiosource
0.01mg
EUR 260
Active Interleukin 10 (IL10)
MBS2122265-005mg
MyBiosource
0.05mg
EUR 560
Active Interleukin 10 (IL10)
MBS2122265-01mg
MyBiosource
0.1mg
EUR 860
Active Interleukin 10 (IL10)
MBS2122265-02mg
MyBiosource
0.2mg
EUR 1060
Active Interleukin 10 (IL10)
MBS2122265-05mg
MyBiosource
0.5mg
EUR 2075
Active Interleukin 11 (IL11)
MBS2122266-001mg
MyBiosource
0.01mg
EUR 250
Active Interleukin 11 (IL11)
MBS2122266-005mg
MyBiosource
0.05mg
EUR 530
Active Interleukin 11 (IL11)
MBS2122266-01mg
MyBiosource
0.1mg
EUR 810
Active Interleukin 11 (IL11)
MBS2122266-02mg
MyBiosource
0.2mg
EUR 1005
Active Interleukin 11 (IL11)
MBS2122266-05mg
MyBiosource
0.5mg
EUR 1950
Active Interleukin 13 (IL13)
MBS2122267-001mg
MyBiosource
0.01mg
EUR 240
Active Interleukin 13 (IL13)
MBS2122267-005mg
MyBiosource
0.05mg
EUR 510
Active Interleukin 13 (IL13)
MBS2122267-01mg
MyBiosource
0.1mg
EUR 785
Active Interleukin 13 (IL13)
MBS2122267-02mg
MyBiosource
0.2mg
EUR 970
Active Interleukin 13 (IL13)
MBS2122267-05mg
MyBiosource
0.5mg
EUR 1880
Active Interleukin 13 (IL13)
MBS2105067-001mg
MyBiosource
0.01mg
EUR 190
Active Interleukin 13 (IL13)
MBS2105067-005mg
MyBiosource
0.05mg
EUR 355
Active Interleukin 13 (IL13)
MBS2105067-01mg
MyBiosource
0.1mg
EUR 540
Active Interleukin 13 (IL13)
MBS2105067-02mg
MyBiosource
0.2mg
EUR 660
Active Interleukin 13 (IL13)
MBS2105067-05mg
MyBiosource
0.5mg
EUR 1270
Active Interleukin 18 (IL18)
MBS2105068-001mg
MyBiosource
0.01mg
EUR 205
Active Interleukin 18 (IL18)
MBS2105068-005mg
MyBiosource
0.05mg
EUR 400
Active Interleukin 18 (IL18)
MBS2105068-01mg
MyBiosource
0.1mg
EUR 610
Active Interleukin 18 (IL18)
MBS2105068-02mg
MyBiosource
0.2mg
EUR 745
Active Interleukin 18 (IL18)
MBS2105068-05mg
MyBiosource
0.5mg
EUR 1430
Active Interleukin 10 (IL10)
MBS2086062-001mg
MyBiosource
0.01mg
EUR 255
Active Interleukin 10 (IL10)
MBS2086062-005mg
MyBiosource
0.05mg
EUR 535
Active Interleukin 10 (IL10)
MBS2086062-01mg
MyBiosource
0.1mg
EUR 825
Active Interleukin 10 (IL10)
MBS2086062-02mg
MyBiosource
0.2mg
EUR 1020
Active Interleukin 10 (IL10)
MBS2086062-05mg
MyBiosource
0.5mg
EUR 1985
Active Interleukin 35 (IL35)
MBS2097218-001mg
MyBiosource
0.01mg
EUR 185
Active Interleukin 35 (IL35)
MBS2097218-005mg
MyBiosource
0.05mg
EUR 340
Active Interleukin 35 (IL35)
MBS2097218-01mg
MyBiosource
0.1mg
EUR 515
Active Interleukin 35 (IL35)
MBS2097218-02mg
MyBiosource
0.2mg
EUR 630
Active Interleukin 35 (IL35)
MBS2097218-05mg
MyBiosource
0.5mg
EUR 1205
Active Interleukin 24 (IL24)
MBS2097224-001mg
MyBiosource
0.01mg
EUR 190
Active Interleukin 24 (IL24)
MBS2097224-005mg
MyBiosource
0.05mg
EUR 355
Active Interleukin 24 (IL24)
MBS2097224-01mg
MyBiosource
0.1mg
EUR 540
Active Interleukin 24 (IL24)
MBS2097224-02mg
MyBiosource
0.2mg
EUR 660
Active Interleukin 24 (IL24)
MBS2097224-05mg
MyBiosource
0.5mg
EUR 1270
Active Interleukin 15 (IL15)
MBS2097226-001mg
MyBiosource
0.01mg
EUR 285
Active Interleukin 15 (IL15)
MBS2097226-005mg
MyBiosource
0.05mg
EUR 630
Active Interleukin 15 (IL15)
MBS2097226-01mg
MyBiosource
0.1mg
EUR 980
Active Interleukin 15 (IL15)
MBS2097226-02mg
MyBiosource
0.2mg
EUR 1205
Active Interleukin 15 (IL15)
MBS2097226-05mg
MyBiosource
0.5mg
EUR 2365
Active Interleukin 18 (IL18)
MBS2097227-001mg
MyBiosource
0.01mg
EUR 200
Active Interleukin 18 (IL18)
MBS2097227-005mg
MyBiosource
0.05mg
EUR 390
Active Interleukin 18 (IL18)
MBS2097227-01mg
MyBiosource
0.1mg
EUR 595
Active Interleukin 18 (IL18)
MBS2097227-02mg
MyBiosource
0.2mg
EUR 725
Active Interleukin 18 (IL18)
MBS2097227-05mg
MyBiosource
0.5mg
EUR 1395
Active Interleukin 16 (IL16)
MBS2097241-001mg
MyBiosource
0.01mg
EUR 265
Active Interleukin 16 (IL16)
MBS2097241-005mg
MyBiosource
0.05mg
EUR 575
Active Interleukin 16 (IL16)
MBS2097241-01mg
MyBiosource
0.1mg
EUR 885
Active Interleukin 16 (IL16)
MBS2097241-02mg
MyBiosource
0.2mg
EUR 1090
Active Interleukin 16 (IL16)
MBS2097241-05mg
MyBiosource
0.5mg
EUR 2130
Active Interleukin 11 (IL11)
MBS2097260-001mg
MyBiosource
0.01mg
EUR 265
Expression of IL – 11 as the neurotrophic cytokine and IL -13 as an anti-inflammatory cytokine with hADSCs can improve immunomodulatory and neuroprotective effects of hADSCs and a strong candidate in stem cell therapies for the future treatment of MS.