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Deoxynivalenol (DON) is an unavoidable contaminants in the Human of food, fodder and agricultural products. Growth retardation in children caused by pollution comprehensive DON has become a global problem that can not be ignored. Previous research has shown that DON causes stunting in children with bowel dysfunction, insulin-like growth factor-1 (IGF-1) axis disruption and peptide YY (PYY). Galanin-like peptide (GALP) is a growth regulator that is important, but its role in DON-induced growth retardation is unclear.
In this study, we report the important role GALP for DON-induced growth inhibition in rat pituitary tumor cell line GH3. DON was found to increase the expression of GALP through hypomethylationin promoter region of GALP gene and upregulate the expression of proinflammatory factors, while downregulate the expression of growth hormone (GH). Furthermore, GALP promoted excessive proinflammatory cytokines, including TNF-α, IL -1β, IL – 11 and IL -6, and will decrease cell viability and cell proliferation, while the inhibitory effect of GALP is the opposite.
GALP expression and insulin-like growth factor binding protein acidic labile subunit (IGFALS) showed the opposite trend, which is the reason the potential regulation of cell proliferation by GALP. Additionally, GALP has anti-apoptotic effects, which can eliminate the inflammatory damage to the cells, thereby contributing to the inhibition of cell growth.
These findings provide new mechanistic insight into the toxicity of DON-induced growth retardation and suggest the therapeutic potential GALP on DON-related diseases.
The immunoregulatory and neuroprotective effects of Human of adipose derived stem cells that express the IL – 11 and IL in the experimental -13 autoimmune encephalomyelitis mice
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) characterized by incomplete endogenous remyelination in the chronic phase. The shift of cytokine balance between pro and anti-inflammatory is one important marker in the patho gene is from MS. This study aimed to evaluate the effect of Human of adipose-derived stem cells (hADSCs) expressing interleukin 11 and interleukin 13 ( IL – 11 , 13-hADSCs) in experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
12 days after immunization C57BL / 6 female mice with MOG35-55 and the early appearance of clinical symptoms, IL – < em> 11 , 13-hADSCs injected via the tail vein into mice EAE. Then, the mice were sacrificed at 30 days post-immunization (DPI) and the spinal cord of the experimental group were extracted for histopathological and real-time RT-PCR results showed that clinical scores studies.
The and infiltration of mononuclear cells into the spinal cords of EAE mice was significantly reduced in mice treated with IL – 11 , 13-hADSCs. Similarly, remyelination and oligodendro gene was significantly improved in the treatment group mentioned. Real-time results show that the cytokine pro / anti-inflammatory gene expression overturned in the IL – 11 , 13-hADSCs treatment group compared to those without EAE untreated group.
Active Interleukin 20 (IL20) |
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| MBS2097236-01mg | MyBiosource | 0.1mg | EUR 560 |
Active Interleukin 20 (IL20) |
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| MBS2097236-02mg | MyBiosource | 0.2mg | EUR 685 |
Active Interleukin 20 (IL20) |
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| MBS2097236-05mg | MyBiosource | 0.5mg | EUR 1315 |
Human Interleukin 20 (IL20) Protein (Active) |
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| 20-abx651390 | Abbexa |
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Human Interleukin 20 (IL20) Protein (Active) |
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| abx651390-5mg | Abbexa | 5 mg | EUR 687.5 |
Recombinant Human Interleukin-20 protein(IL20) (Active) |
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| AP73473 | SAB | 1mg | EUR 6829 |
Recombinant Human Interleukin-20 protein (IL20) (Active) |
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| CSB-AP001871HU | Cusabio | 8269 mg | Ask for price |
Recombinant Human Interleukin-20 protein (IL20) (Active) |
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| MBS969305-001mg | MyBiosource | 0.01mg | EUR 355 |
Recombinant Human Interleukin-20 protein (IL20) (Active) |
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| MBS969305-01mg | MyBiosource | 0.1mg | EUR 1590 |
Recombinant Human Interleukin-20 protein (IL20) (Active) |
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| MBS969305-05mg | MyBiosource | 0.5mg | EUR 3395 |
Recombinant Human Interleukin-20 protein (IL20) (Active) |
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| MBS969305-5x05mg | MyBiosource | 5x0.5mg | EUR 15240 |
Active Interleukin 10 (IL10) |
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| APA056Bo61 | Cloud-Clone | 10ug | EUR 368 |
Active Interleukin 10 (IL10) |
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| APA056Ca61 | Cloud-Clone | 10ug | EUR 328 |
Active Interleukin 10 (IL10) |
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| APA056Eq61 | Cloud-Clone | 10ug | EUR 380 |
Active Interleukin 10 (IL10) |
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| APA056Ga61 | Cloud-Clone | 10ug | EUR 319 |
Active Interleukin 10 (IL10) |
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| APA056Hu61 | Cloud-Clone | 10ug | EUR 335 |
Active Interleukin 10 (IL10) |
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| 4-APA056Hu61 | Cloud-Clone |
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Description: Recombinant Human Interleukin 10 expressed in: 293F cell |
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Active Interleukin 10 (IL10) |
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| APA056Mu61 | Cloud-Clone | 10ug | EUR 324 |
Active Interleukin 10 (IL10) |
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| APA056Ra01 | Cloud-Clone | 10ug | EUR 350 |
Active Interleukin 10 (IL10) |
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| APA056Ra61 | Cloud-Clone | 10ug | EUR 251 |
Active Interleukin 10 (IL10) |
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| APA056Rb61 | Cloud-Clone | 10ug | EUR 331 |
Active Interleukin 11 (IL11) |
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| APA057Hu01 | Cloud-Clone | 10ug | EUR 360 |
Active Interleukin 11 (IL11) |
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| 4-APA057Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 11 expressed in: E.coli |
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Active Interleukin 11 (IL11) |
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| APA057Hu61 | Cloud-Clone | 10ug | EUR 328 |
Active Interleukin 11 (IL11) |
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| APA057Hu62 | Cloud-Clone | 10ug | EUR 332 |
Active Interleukin 13 (IL13) |
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| APA060Hu01 | Cloud-Clone | 10ug | EUR 317 |
Active Interleukin 13 (IL13) |
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| APA060Ra01 | Cloud-Clone | 10ug | EUR 211 |
Active Interleukin 13 (IL13) |
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| 4-APA060Ra01 | Cloud-Clone |
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Description: Recombinant Rat Active Interleukin 13 (IL13) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 15 (IL15) |
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| APA061Hu01 | Cloud-Clone | 10ug | EUR 400 |
Active Interleukin 15 (IL15) |
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| 4-APA061Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 15 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 16 (IL16) |
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| APA062Hu01 | Cloud-Clone | 10ug | EUR 360 |
Active Interleukin 16 (IL16) |
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| 4-APA062Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 16 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 17 (IL17) |
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| APA063Hu01 | Cloud-Clone | 10ug | EUR 167 |
Active Interleukin 17 (IL17) |
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| 4-APA063Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 17 expressed in: E.coli |
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Active Interleukin 17 (IL17) |
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| APA063Mu61 | Cloud-Clone | 10ug | EUR 272 |
Active Interleukin 17 (IL17) |
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| APA063Po61 | Cloud-Clone | 10ug | EUR 280 |
Active Interleukin 18 (IL18) |
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| APA064Hu01 | Cloud-Clone | 10ug | EUR 239 |
Active Interleukin 18 (IL18) |
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| 4-APA064Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 18 (IL18) |
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| APA064Mu01 | Cloud-Clone | 10ug | EUR 233 |
Active Interleukin 18 (IL18) |
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| 4-APA064Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 19 (IL19) |
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| APB190Hu61 | Cloud-Clone | 10ug | EUR 350 |
Active Interleukin 19 (IL19) |
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| APB190Mu61 | Cloud-Clone | 10ug | EUR 380 |
Active Interleukin 19 (IL19) |
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| APB190Ra61 | Cloud-Clone | 10ug | EUR 372 |
Active Interleukin 21 (IL21) |
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| APB688Hu01 | Cloud-Clone | 10ug | EUR 250 |
Active Interleukin 21 (IL21) |
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| 4-APB688Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 21 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 21 (IL21) |
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| APB688Hu61 | Cloud-Clone | 10ug | EUR 300 |
Active Interleukin 21 (IL21) |
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| APB688Ra61 | Cloud-Clone | 10ug | EUR 269 |
Active Interleukin 25 (IL25) |
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| APB694Hu01 | Cloud-Clone | 10ug | EUR 240 |
Active Interleukin 25 (IL25) |
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| 4-APB694Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 25 expressed in: E.coli |
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Active Interleukin 25 (IL25) |
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| APB694Hu61 | Cloud-Clone | 10ug | EUR 280 |
Active Interleukin 25 (IL25) |
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| APB694Ra61 | Cloud-Clone | 10ug | EUR 272 |
Active Interleukin 33 (IL33) |
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| APB980Hu01 | Cloud-Clone | 10ug | EUR 328 |
Active Interleukin 33 (IL33) |
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| 4-APB980Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 33 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 34 (IL34) |
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| APC007Hu01 | Cloud-Clone | 10ug | EUR 252 |
Active Interleukin 34 (IL34) |
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| 4-APC007Hu01 | Cloud-Clone |
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Description: Recombinant Human Active Interleukin 34 (IL34) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 34 (IL34) |
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| APC007Hu61 | Cloud-Clone | 10ug | EUR 316 |
Active Interleukin 34 (IL34) |
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| APC007Mu01 | Cloud-Clone | 10ug | EUR 326 |
Active Interleukin 34 (IL34) |
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| APC007Mu61 | Cloud-Clone | 10ug | EUR 320 |
Active Interleukin 35 (IL35) |
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| APC008Hu01 | Cloud-Clone | 10ug | EUR 200 |
Active Interleukin 35 (IL35) |
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| 4-APC008Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 35 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 29 (IL29) |
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| APC029Hu01 | Cloud-Clone | 10ug | EUR 211 |
Active Interleukin 29 (IL29) |
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| 4-APC029Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 29 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 29 (IL29) |
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| APC029Ra61 | Cloud-Clone | 10ug | EUR 280 |
Active Interleukin 22 (IL22) |
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| APC032Hu01 | Cloud-Clone | 10ug | EUR 324 |
Active Interleukin 22 (IL22) |
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| 4-APC032Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 22 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 22 (IL22) |
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| APC032Hu61 | Cloud-Clone | 10ug | EUR 324 |
Active Interleukin 22 (IL22) |
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| APC032Mu61 | Cloud-Clone | 10ug | EUR 276 |
Active Interleukin 24 (IL24) |
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| APC064Hu01 | Cloud-Clone | 10ug | EUR 211 |
Active Interleukin 24 (IL24) |
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| 4-APC064Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 24 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
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Active Interleukin 23 (IL23) |
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| APX262Mu61 | Cloud-Clone | 10ug | EUR 340 |
Active Interleukin 13 (IL13) |
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| RPU55465-100ug | Biomatik Corporation | 100ug | EUR 651.2 |
Active Interleukin 13 (IL13) |
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| RPU55465-1mg | Biomatik Corporation | 1mg | EUR 3294.2 |
Active Interleukin 13 (IL13) |
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| RPU55465-50ug | Biomatik Corporation | 50ug | EUR 506.9 |
Active Interleukin 18 (IL18) |
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| RPU55467-100ug | Biomatik Corporation | 100ug | EUR 739.2 |
Active Interleukin 18 (IL18) |
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| RPU55467-1mg | Biomatik Corporation | 1mg | EUR 3731 |
Active Interleukin 18 (IL18) |
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| RPU55467-50ug | Biomatik Corporation | 50ug | EUR 574.1 |
Active Interleukin 21 (IL21) |
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| RPU55704-100ug | Biomatik Corporation | 100ug | EUR 997.7 |
Active Interleukin 21 (IL21) |
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| RPU55704-1mg | Biomatik Corporation | 1mg | EUR 3893.5 |
Active Interleukin 21 (IL21) |
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| RPU55704-50ug | Biomatik Corporation | 50ug | EUR 599.1 |
Active Interleukin 33 (IL33) |
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| RPU55739-100ug | Biomatik Corporation | 100ug | EUR 1013.1 |
Active Interleukin 33 (IL33) |
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| RPU55739-1mg | Biomatik Corporation | 1mg | EUR 5116.8 |
Active Interleukin 33 (IL33) |
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| RPU55739-50ug | Biomatik Corporation | 50ug | EUR 787.2 |
Active Interleukin 34 (IL34) |
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| RPU55743-100ug | Biomatik Corporation | 100ug | EUR 997.7 |
Active Interleukin 34 (IL34) |
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| RPU55743-1mg | Biomatik Corporation | 1mg | EUR 3931.2 |
Active Interleukin 34 (IL34) |
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| RPU55743-50ug | Biomatik Corporation | 50ug | EUR 604.8 |
Active Interleukin 29 (IL29) |
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| RPU55746-100ug | Biomatik Corporation | 100ug | EUR 651.2 |
Active Interleukin 29 (IL29) |
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| RPU55746-1mg | Biomatik Corporation | 1mg | EUR 3294.2 |
Active Interleukin 29 (IL29) |
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| RPU55746-50ug | Biomatik Corporation | 50ug | EUR 506.9 |
Active Interleukin 22 (IL22) |
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| RPU55748-100ug | Biomatik Corporation | 100ug | EUR 1282.6 |
Active Interleukin 22 (IL22) |
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| RPU55748-1mg | Biomatik Corporation | 1mg | EUR 5054.4 |
Active Interleukin 22 (IL22) |
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| RPU55748-50ug | Biomatik Corporation | 50ug | EUR 777.6 |
Active Interleukin 13 (IL13) |
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| RPU56351-100ug | Biomatik Corporation | 100ug | EUR 985.6 |
Active Interleukin 13 (IL13) |
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| RPU56351-1mg | Biomatik Corporation | 1mg | EUR 4941.3 |
Active Interleukin 13 (IL13) |
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| RPU56351-50ug | Biomatik Corporation | 50ug | EUR 760.4 |
Active Interleukin 10 (IL10) |
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| RPU56353-100ug | Biomatik Corporation | 100ug | EUR 1282.6 |
Active Interleukin 10 (IL10) |
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| RPU56353-1mg | Biomatik Corporation | 1mg | EUR 5054.4 |
Active Interleukin 10 (IL10) |
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| RPU56353-50ug | Biomatik Corporation | 50ug | EUR 777.6 |
Active Interleukin 10 (IL10) |
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| RPU56368-100ug | Biomatik Corporation | 100ug | EUR 1078 |
Active Interleukin 10 (IL10) |
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| RPU56368-1mg | Biomatik Corporation | 1mg | EUR 4777.5 |
Active Interleukin 10 (IL10) |
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| RPU56368-50ug | Biomatik Corporation | 50ug | EUR 866.8 |
Active Interleukin 32 (IL32) |
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| RPU58896-100ug | Biomatik Corporation | 100ug | EUR 709.8 |
Active Interleukin 32 (IL32) |
|||
| RPU58896-1mg | Biomatik Corporation | 1mg | EUR 3294.7 |
Active Interleukin 32 (IL32) |
|||
| RPU58896-50ug | Biomatik Corporation | 50ug | EUR 522.7 |
Active Interleukin 19 (IL19) |
|||
| RPU58930-100ug | Biomatik Corporation | 100ug | EUR 868.2 |
Active Interleukin 19 (IL19) |
|||
| RPU58930-1mg | Biomatik Corporation | 1mg | EUR 3419.5 |
Active Interleukin 19 (IL19) |
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| RPU58930-50ug | Biomatik Corporation | 50ug | EUR 542.5 |
Active Interleukin 10 (IL10) |
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| RPU59057-100ug | Biomatik Corporation | 100ug | EUR 939.7 |
Active Interleukin 10 (IL10) |
|||
| RPU59057-1mg | Biomatik Corporation | 1mg | EUR 3673.8 |
Active Interleukin 10 (IL10) |
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| RPU59057-50ug | Biomatik Corporation | 50ug | EUR 587.2 |
Active Interleukin 31 (IL31) |
|||
| RPU59177-100ug | Biomatik Corporation | 100ug | EUR 1084.2 |
Active Interleukin 31 (IL31) |
|||
| RPU59177-1mg | Biomatik Corporation | 1mg | EUR 4504.5 |
Active Interleukin 31 (IL31) |
|||
| RPU59177-50ug | Biomatik Corporation | 50ug | EUR 720 |
Active Interleukin 22 (IL22) |
|||
| RPU59213-100ug | Biomatik Corporation | 100ug | EUR 1069.2 |
Active Interleukin 22 (IL22) |
|||
| RPU59213-1mg | Biomatik Corporation | 1mg | EUR 4738.5 |
Active Interleukin 22 (IL22) |
|||
| RPU59213-50ug | Biomatik Corporation | 50ug | EUR 712.8 |
Active Interleukin 10 (IL10) |
|||
| RPU59216-100ug | Biomatik Corporation | 100ug | EUR 1082.4 |
Active Interleukin 10 (IL10) |
|||
| RPU59216-1mg | Biomatik Corporation | 1mg | EUR 4797 |
Active Interleukin 10 (IL10) |
|||
| RPU59216-50ug | Biomatik Corporation | 50ug | EUR 721.6 |
Active Interleukin 11 (IL11) |
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| RPU59219-100ug | Biomatik Corporation | 100ug | EUR 1084.1 |
Active Interleukin 11 (IL11) |
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| RPU59219-1mg | Biomatik Corporation | 1mg | EUR 4802.9 |
Active Interleukin 11 (IL11) |
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| RPU59219-50ug | Biomatik Corporation | 50ug | EUR 722.5 |
Active Interleukin 26 (IL26) |
|||
| RPU59230-100ug | Biomatik Corporation | 100ug | EUR 1093.1 |
Active Interleukin 26 (IL26) |
|||
| RPU59230-1mg | Biomatik Corporation | 1mg | EUR 4843.8 |
Active Interleukin 26 (IL26) |
|||
| RPU59230-50ug | Biomatik Corporation | 50ug | EUR 728.6 |
Active Interleukin 25 (IL25) |
|||
| RPU54937-100ug | Biomatik Corporation | 100ug | EUR 739.2 |
Active Interleukin 25 (IL25) |
|||
| RPU54937-1mg | Biomatik Corporation | 1mg | EUR 3276 |
Active Interleukin 25 (IL25) |
|||
| RPU54937-50ug | Biomatik Corporation | 50ug | EUR 594 |
Active Interleukin 35 (IL35) |
|||
| RPU54947-100ug | Biomatik Corporation | 100ug | EUR 616 |
Active Interleukin 35 (IL35) |
|||
| RPU54947-1mg | Biomatik Corporation | 1mg | EUR 2730 |
Active Interleukin 35 (IL35) |
|||
| RPU54947-50ug | Biomatik Corporation | 50ug | EUR 495 |
Active Interleukin 24 (IL24) |
|||
| RPU54949-100ug | Biomatik Corporation | 100ug | EUR 651.2 |
Active Interleukin 24 (IL24) |
|||
| RPU54949-1mg | Biomatik Corporation | 1mg | EUR 3294.2 |
Active Interleukin 24 (IL24) |
|||
| RPU54949-50ug | Biomatik Corporation | 50ug | EUR 506.9 |
Active Interleukin 10 (IL10) |
|||
| RPU54838-100ug | Biomatik Corporation | 100ug | EUR 1030.7 |
Active Interleukin 10 (IL10) |
|||
| RPU54838-1mg | Biomatik Corporation | 1mg | EUR 4569.5 |
Active Interleukin 10 (IL10) |
|||
| RPU54838-50ug | Biomatik Corporation | 50ug | EUR 828.3 |
Active Interleukin 11 (IL11) |
|||
| RPU54855-100ug | Biomatik Corporation | 100ug | EUR 1108.8 |
Active Interleukin 11 (IL11) |
|||
| RPU54855-1mg | Biomatik Corporation | 1mg | EUR 4914 |
Active Interleukin 11 (IL11) |
|||
| RPU54855-50ug | Biomatik Corporation | 50ug | EUR 891 |
Active Interleukin 15 (IL15) |
|||
| RPU54856-100ug | Biomatik Corporation | 100ug | EUR 1232 |
Active Interleukin 15 (IL15) |
|||
| RPU54856-1mg | Biomatik Corporation | 1mg | EUR 6240 |
Active Interleukin 15 (IL15) |
|||
| RPU54856-50ug | Biomatik Corporation | 50ug | EUR 990 |
Active Interleukin 16 (IL16) |
|||
| RPU54857-100ug | Biomatik Corporation | 100ug | EUR 1108.8 |
Active Interleukin 16 (IL16) |
|||
| RPU54857-1mg | Biomatik Corporation | 1mg | EUR 4914 |
Active Interleukin 16 (IL16) |
|||
| RPU54857-50ug | Biomatik Corporation | 50ug | EUR 891 |
Active Interleukin 17 (IL17) |
|||
| RPU54858-100ug | Biomatik Corporation | 100ug | EUR 514.8 |
Active Interleukin 17 (IL17) |
|||
| RPU54858-1mg | Biomatik Corporation | 1mg | EUR 2607.8 |
Active Interleukin 17 (IL17) |
|||
| RPU54858-50ug | Biomatik Corporation | 50ug | EUR 401.3 |
Active Interleukin 18 (IL18) |
|||
| RPU54859-100ug | Biomatik Corporation | 100ug | EUR 722.7 |
Active Interleukin 18 (IL18) |
|||
| RPU54859-1mg | Biomatik Corporation | 1mg | EUR 3199.3 |
Active Interleukin 18 (IL18) |
|||
| RPU54859-50ug | Biomatik Corporation | 50ug | EUR 579.7 |
Active Interleukin 10 (IL10) |
|||
| MBS2122264-001mg | MyBiosource | 0.01mg | EUR 245 |
Active Interleukin 10 (IL10) |
|||
| MBS2122264-005mg | MyBiosource | 0.05mg | EUR 520 |
Active Interleukin 10 (IL10) |
|||
| MBS2122264-01mg | MyBiosource | 0.1mg | EUR 800 |
Active Interleukin 10 (IL10) |
|||
| MBS2122264-02mg | MyBiosource | 0.2mg | EUR 990 |
Active Interleukin 10 (IL10) |
|||
| MBS2122264-05mg | MyBiosource | 0.5mg | EUR 1925 |
Active Interleukin 10 (IL10) |
|||
| MBS2122265-001mg | MyBiosource | 0.01mg | EUR 260 |
Active Interleukin 10 (IL10) |
|||
| MBS2122265-005mg | MyBiosource | 0.05mg | EUR 560 |
Active Interleukin 10 (IL10) |
|||
| MBS2122265-01mg | MyBiosource | 0.1mg | EUR 860 |
Expression of IL – 11 as the neurotrophic cytokine and IL -13 as an anti-inflammatory cytokine with hADSCs can improve immunomodulatory and neuroprotective effects of hADSCs and a strong candidate in stem cell therapies for the future treatment of MS.
