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Epigenetic upregulation of galanin-like peptide mediates deoxynivalenol induced-growth inhibition in pituitary cells

Epigenetic upregulation of galanin-like peptide mediates deoxynivalenol induced-growth inhibition in pituitary cells
Posted by Rachael

Deoxynivalenol (DON) is an unavoidable contaminants in the Human of food, fodder and agricultural products. Growth retardation in children caused by pollution comprehensive DON has become a global problem that can not be ignored. Previous research has shown that DON causes stunting in children with bowel dysfunction, insulin-like growth factor-1 (IGF-1) axis disruption and peptide YY (PYY). Galanin-like peptide (GALP) is a growth regulator that is important, but its role in DON-induced growth retardation is unclear.

In this study, we report the important role GALP for DON-induced growth inhibition in rat pituitary tumor cell line GH3. DON was found to increase the expression of GALP through hypomethylationin promoter region of GALP gene and upregulate the expression of proinflammatory factors, while downregulate the expression of growth hormone (GH). Furthermore, GALP promoted excessive proinflammatory cytokines, including TNF-α, IL -1β, IL – 11 and IL -6, and will decrease cell viability and cell proliferation, while the inhibitory effect of GALP is the opposite.

GALP expression and insulin-like growth factor binding protein acidic labile subunit (IGFALS) showed the opposite trend, which is the reason the potential regulation of cell proliferation by GALP. Additionally, GALP has anti-apoptotic effects, which can eliminate the inflammatory damage to the cells, thereby contributing to the inhibition of cell growth.

These findings provide new mechanistic insight into the toxicity of DON-induced growth retardation and suggest the therapeutic potential GALP on DON-related diseases.

Epigenetic upregulation of galanin-like peptide mediates deoxynivalenol induced-growth inhibition in pituitary cells
Epigenetic upregulation of galanin-like peptide mediates deoxynivalenol induced-growth inhibition in pituitary cells

The immunoregulatory and neuroprotective effects of Human of adipose derived stem cells that express the IL – 11 and IL in the experimental -13 autoimmune encephalomyelitis mice

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) characterized by incomplete endogenous remyelination in the chronic phase. The shift of cytokine balance between pro and anti-inflammatory is one important marker in the patho gene is from MS. This study aimed to evaluate the effect of Human of adipose-derived stem cells (hADSCs) expressing interleukin 11 and interleukin 13 ( IL – 11 , 13-hADSCs) in experimental autoimmune encephalomyelitis (EAE), an animal model of MS.

12 days after immunization C57BL / 6 female mice with MOG35-55 and the early appearance of clinical symptoms, IL – < em> 11 , 13-hADSCs injected via the tail vein into mice EAE. Then, the mice were sacrificed at 30 days post-immunization (DPI) and the spinal cord of the experimental group were extracted for histopathological and real-time RT-PCR results showed that clinical scores studies.

The and infiltration of mononuclear cells into the spinal cords of EAE mice was significantly reduced in mice treated with IL – 11 , 13-hADSCs. Similarly, remyelination and oligodendro gene was significantly improved in the treatment group mentioned. Real-time results show that the cytokine pro / anti-inflammatory gene expression overturned in the IL – 11 , 13-hADSCs treatment group compared to those without EAE untreated group.

Recombinant Human Interleukin-20 protein(IL20) (Active)

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Recombinant Human Interleukin-20 protein (IL20) (Active)

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Active Interleukin 23 (IL23)

APX262Mu61 10ug
EUR 340

Active Interleukin 19 (IL19)

APB190Hu61 10ug
EUR 350

Active Interleukin 19 (IL19)

APB190Mu61 10ug
EUR 380

Active Interleukin 19 (IL19)

APB190Ra61 10ug
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Active Interleukin 21 (IL21)

APB688Hu01 10ug
EUR 250

Active Interleukin 21 (IL21)

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Active Interleukin 21 (IL21)

APB688Hu61 10ug
EUR 300

Active Interleukin 21 (IL21)

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EUR 269

Active Interleukin 25 (IL25)

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EUR 240

Active Interleukin 25 (IL25)

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Description: Recombinant Human Interleukin 25 expressed in: E.coli

Active Interleukin 25 (IL25)

APB694Hu61 10ug
EUR 280

Active Interleukin 25 (IL25)

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Active Interleukin 33 (IL33)

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EUR 328

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Description: Recombinant Human Interleukin 33 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 34 (IL34)

APC007Hu01 10ug
EUR 252

Active Interleukin 34 (IL34)

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Description: Recombinant Human Active Interleukin 34 (IL34) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 34 (IL34)

APC007Hu61 10ug
EUR 316

Active Interleukin 34 (IL34)

APC007Mu01 10ug
EUR 326

Active Interleukin 34 (IL34)

APC007Mu61 10ug
EUR 320

Active Interleukin 35 (IL35)

APC008Hu01 10ug
EUR 200

Active Interleukin 35 (IL35)

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Description: Recombinant Human Interleukin 35 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 29 (IL29)

APC029Hu01 10ug
EUR 211

Active Interleukin 29 (IL29)

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Description: Recombinant Human Interleukin 29 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 29 (IL29)

APC029Ra61 10ug
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Active Interleukin 22 (IL22)

APC032Hu01 10ug
EUR 324

Active Interleukin 22 (IL22)

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Description: Recombinant Human Interleukin 22 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 22 (IL22)

APC032Hu61 10ug
EUR 324

Active Interleukin 22 (IL22)

APC032Mu61 10ug
EUR 276

Active Interleukin 24 (IL24)

APC064Hu01 10ug
EUR 211

Active Interleukin 24 (IL24)

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Description: Recombinant Human Interleukin 24 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 10 (IL10)

APA056Bo61 10ug
EUR 368

Active Interleukin 10 (IL10)

APA056Ca61 10ug
EUR 328

Active Interleukin 10 (IL10)

APA056Eq61 10ug
EUR 380

Active Interleukin 10 (IL10)

APA056Ga61 10ug
EUR 319

Active Interleukin 10 (IL10)

APA056Hu61 10ug
EUR 335

Active Interleukin 10 (IL10)

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Description: Recombinant Human Interleukin 10 expressed in: 293F cell

Active Interleukin 10 (IL10)

APA056Mu61 10ug
EUR 324

Active Interleukin 10 (IL10)

APA056Ra01 10ug
EUR 350

Active Interleukin 10 (IL10)

APA056Ra61 10ug
EUR 251

Active Interleukin 10 (IL10)

APA056Rb61 10ug
EUR 331

Active Interleukin 11 (IL11)

APA057Hu01 10ug
EUR 360

Active Interleukin 11 (IL11)

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Description: Recombinant Human Interleukin 11 expressed in: E.coli

Active Interleukin 11 (IL11)

APA057Hu61 10ug
EUR 328

Active Interleukin 11 (IL11)

APA057Hu62 10ug
EUR 332

Active Interleukin 13 (IL13)

APA060Hu01 10ug
EUR 317

Active Interleukin 13 (IL13)

APA060Ra01 10ug
EUR 211

Active Interleukin 13 (IL13)

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Description: Recombinant Rat Active Interleukin 13 (IL13) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 15 (IL15)

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Description: Recombinant Human Interleukin 15 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 16 (IL16)

APA062Hu01 10ug
EUR 360

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Description: Recombinant Human Interleukin 16 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 17 (IL17)

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Description: Recombinant Human Interleukin 17 expressed in: E.coli

Active Interleukin 17 (IL17)

APA063Mu61 10ug
EUR 272

Active Interleukin 17 (IL17)

APA063Po61 10ug
EUR 280

Active Interleukin 18 (IL18)

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EUR 239

Active Interleukin 18 (IL18)

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Description: Recombinant Human Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 18 (IL18)

APA064Mu01 10ug
EUR 233

Active Interleukin 18 (IL18)

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Description: Recombinant Mouse Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 32 (IL32)

RPU58896-100ug 100ug
EUR 709.8

Active Interleukin 32 (IL32)

RPU58896-1mg 1mg
EUR 3294.7

Active Interleukin 32 (IL32)

RPU58896-50ug 50ug
EUR 522.7

Active Interleukin 19 (IL19)

RPU58930-100ug 100ug
EUR 868.2

Active Interleukin 19 (IL19)

RPU58930-1mg 1mg
EUR 3419.5

Active Interleukin 19 (IL19)

RPU58930-50ug 50ug
EUR 542.5

Active Interleukin 10 (IL10)

RPU59057-100ug 100ug
EUR 939.7

Active Interleukin 10 (IL10)

RPU59057-1mg 1mg
EUR 3673.8

Active Interleukin 10 (IL10)

RPU59057-50ug 50ug
EUR 587.2

Active Interleukin 31 (IL31)

RPU59177-100ug 100ug
EUR 1084.2

Active Interleukin 31 (IL31)

RPU59177-1mg 1mg
EUR 4504.5

Active Interleukin 31 (IL31)

RPU59177-50ug 50ug
EUR 720

Active Interleukin 22 (IL22)

RPU59213-100ug 100ug
EUR 1069.2

Active Interleukin 22 (IL22)

RPU59213-1mg 1mg
EUR 4738.5

Active Interleukin 22 (IL22)

RPU59213-50ug 50ug
EUR 712.8

Active Interleukin 10 (IL10)

RPU59216-100ug 100ug
EUR 1082.4

Active Interleukin 10 (IL10)

RPU59216-1mg 1mg
EUR 4797

Active Interleukin 10 (IL10)

RPU59216-50ug 50ug
EUR 721.6

Active Interleukin 11 (IL11)

RPU59219-100ug 100ug
EUR 1084.1

Active Interleukin 11 (IL11)

RPU59219-1mg 1mg
EUR 4802.9

Active Interleukin 11 (IL11)

RPU59219-50ug 50ug
EUR 722.5

Active Interleukin 26 (IL26)

RPU59230-100ug 100ug
EUR 1093.1

Active Interleukin 26 (IL26)

RPU59230-1mg 1mg
EUR 4843.8

Active Interleukin 26 (IL26)

RPU59230-50ug 50ug
EUR 728.6

Active Interleukin 13 (IL13)

RPU56351-100ug 100ug
EUR 985.6

Active Interleukin 13 (IL13)

RPU56351-1mg 1mg
EUR 4941.3

Active Interleukin 13 (IL13)

RPU56351-50ug 50ug
EUR 760.4

Active Interleukin 10 (IL10)

RPU56353-100ug 100ug
EUR 1282.6

Active Interleukin 10 (IL10)

RPU56353-1mg 1mg
EUR 5054.4

Active Interleukin 10 (IL10)

RPU56353-50ug 50ug
EUR 777.6

Active Interleukin 10 (IL10)

RPU56368-100ug 100ug
EUR 1078

Active Interleukin 10 (IL10)

RPU56368-1mg 1mg
EUR 4777.5

Active Interleukin 10 (IL10)

RPU56368-50ug 50ug
EUR 866.8

Active Interleukin 13 (IL13)

RPU55465-100ug 100ug
EUR 651.2

Active Interleukin 13 (IL13)

RPU55465-1mg 1mg
EUR 3294.2

Active Interleukin 13 (IL13)

RPU55465-50ug 50ug
EUR 506.9

Active Interleukin 18 (IL18)

RPU55467-100ug 100ug
EUR 739.2

Active Interleukin 18 (IL18)

RPU55467-1mg 1mg
EUR 3731

Active Interleukin 18 (IL18)

RPU55467-50ug 50ug
EUR 574.1

Active Interleukin 21 (IL21)

RPU55704-100ug 100ug
EUR 997.7

Active Interleukin 21 (IL21)

RPU55704-1mg 1mg
EUR 3893.5

Active Interleukin 21 (IL21)

RPU55704-50ug 50ug
EUR 599.1

Active Interleukin 33 (IL33)

RPU55739-100ug 100ug
EUR 1013.1

Active Interleukin 33 (IL33)

RPU55739-1mg 1mg
EUR 5116.8

Active Interleukin 33 (IL33)

RPU55739-50ug 50ug
EUR 787.2

Active Interleukin 34 (IL34)

RPU55743-100ug 100ug
EUR 997.7

Active Interleukin 34 (IL34)

RPU55743-1mg 1mg
EUR 3931.2

Active Interleukin 34 (IL34)

RPU55743-50ug 50ug
EUR 604.8

Active Interleukin 29 (IL29)

RPU55746-100ug 100ug
EUR 651.2

Active Interleukin 29 (IL29)

RPU55746-1mg 1mg
EUR 3294.2

Active Interleukin 29 (IL29)

RPU55746-50ug 50ug
EUR 506.9

Active Interleukin 22 (IL22)

RPU55748-100ug 100ug
EUR 1282.6

Active Interleukin 22 (IL22)

RPU55748-1mg 1mg
EUR 5054.4

Active Interleukin 22 (IL22)

RPU55748-50ug 50ug
EUR 777.6

Active Interleukin 25 (IL25)

RPU54937-100ug 100ug
EUR 739.2

Active Interleukin 25 (IL25)

RPU54937-1mg 1mg
EUR 3276

Active Interleukin 25 (IL25)

RPU54937-50ug 50ug
EUR 594

Active Interleukin 35 (IL35)

RPU54947-100ug 100ug
EUR 616

Active Interleukin 35 (IL35)

RPU54947-1mg 1mg
EUR 2730

Active Interleukin 35 (IL35)

RPU54947-50ug 50ug
EUR 495

Active Interleukin 24 (IL24)

RPU54949-100ug 100ug
EUR 651.2

Active Interleukin 24 (IL24)

RPU54949-1mg 1mg
EUR 3294.2

Active Interleukin 24 (IL24)

RPU54949-50ug 50ug
EUR 506.9

Active Interleukin 10 (IL10)

RPU54838-100ug 100ug
EUR 1030.7

Active Interleukin 10 (IL10)

RPU54838-1mg 1mg
EUR 4569.5

Active Interleukin 10 (IL10)

RPU54838-50ug 50ug
EUR 828.3

Active Interleukin 11 (IL11)

RPU54855-100ug 100ug
EUR 1108.8

Active Interleukin 11 (IL11)

RPU54855-1mg 1mg
EUR 4914

Active Interleukin 11 (IL11)

RPU54855-50ug 50ug
EUR 891

Active Interleukin 15 (IL15)

RPU54856-100ug 100ug
EUR 1232

Active Interleukin 15 (IL15)

RPU54856-1mg 1mg
EUR 6240

Active Interleukin 15 (IL15)

RPU54856-50ug 50ug
EUR 990

Active Interleukin 16 (IL16)

RPU54857-100ug 100ug
EUR 1108.8

Active Interleukin 16 (IL16)

RPU54857-1mg 1mg
EUR 4914

Active Interleukin 16 (IL16)

RPU54857-50ug 50ug
EUR 891

Active Interleukin 17 (IL17)

RPU54858-100ug 100ug
EUR 514.8

Active Interleukin 17 (IL17)

RPU54858-1mg 1mg
EUR 2607.8

Active Interleukin 17 (IL17)

RPU54858-50ug 50ug
EUR 401.3

Active Interleukin 18 (IL18)

RPU54859-100ug 100ug
EUR 722.7

Active Interleukin 18 (IL18)

RPU54859-1mg 1mg
EUR 3199.3

Active Interleukin 18 (IL18)

RPU54859-50ug 50ug
EUR 579.7

Active Interleukin 7 (IL7)

APA662Hu01 10ug
EUR 325

Active Interleukin 7 (IL7)

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Description: Recombinant Human Interleukin 7 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 7 (IL7)

APA662Hu61 10ug
EUR 320

Active Interleukin 2 (IL2)

APA073Eq61 10ug
EUR 360

Active Interleukin 2 (IL2)

APA073Gu01 10ug
EUR 247

Active Interleukin 2 (IL2)

APA073Hu01 10ug
EUR 227

Active Interleukin 2 (IL2)

APA073Hu02 10ug
EUR 229

Active Interleukin 2 (IL2)

APA073Hu61 10ug
EUR 280

Active Interleukin 2 (IL2)

4-APA073Hu61
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Description: Recombinant Human Interleukin 2 expressed in: 293F cell

Active Interleukin 2 (IL2)

APA073Mu61 10ug
EUR 147

Active Interleukin 2 (IL2)

4-APA073Mu61
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Description: Recombinant Mouse Interleukin 2 expressed in: 293F cell

Active Interleukin 2 (IL2)

APA073Po01 10ug
EUR 255

Active Interleukin 2 (IL2)

APA073Po61 10ug
EUR 360

Active Interleukin 2 (IL2)

APA073Ra61 10ug
EUR 302

Active Interleukin 3 (IL3)

APA076Ca61 10ug
EUR 360

Active Interleukin 3 (IL3)

APA076Hu61 10ug
EUR 319

Active Interleukin 3 (IL3)

APA076Mu61 10ug
EUR 312

Expression of IL – 11 as the neurotrophic cytokine and IL -13 as an anti-inflammatory cytokine with hADSCs can improve immunomodulatory and neuroprotective effects of hADSCs and a strong candidate in stem cell therapies for the future treatment of MS.

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Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits, Uncategorized, Vector & Virus, Western Blot

Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.

Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.

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