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Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.

Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.
Posted by Rachael

Is the seminal plasma (SP) and its constituents affect decidualizing capacity and transcriptome of Human main endometrial stromal fibroblasts (eSFs)? SP promoting decidualizing of eSFs of women with and without inflammatory disorders (polycystic ovary syndrome (PCOS), endometriosis) in a way that is not mediated by amyloid semen and those associated with the response transcription powerful, including the induction of interleukin ( IL ) – 11 , cytokines important for the SP-induced decidualizing.

Clinical studies have shown that SP may promote implantation, and in vitro studies have shown that SP can promote decidualizing, steroid hormone driven program differentiation of the ESF which is essential for embryo implantation and impaired in women with disorders of PCOS inflammatory and endometriosis. This is a cross-sectional study in volving samples treated with vehicle alone compared to treatment with SP or SP constituents. SP was tested for the ability to promote decidualizing in vitro in eSFs of women with or without PCOS or endometriosis (n = 9). The role of amyloid semen and SP fractionated in mediating these effects and in eliciting changes in transcription in eSFs were studied.

Finally, the role of IL -. 11 , cytokines with a key role in the implantation and decidualizing, rated as a mediator of decidualizing SP-facilitated eSFs and endometrial epithelial cells (EECS) was isolated from a biopsy of the endometrium of women of reproductive age undergoing benign gynecological procedure and maintained in vitro. Tests were performed to assess whether treatment with SP or SP eSFs constituents affect the rate and extent of decidualizing in women with and without inflammatory disorders.

Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.
Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.

To characterize the response of the endometrium to SP and SP constituents, RNA was isolated from treated or EECS eSFs and analyzed by RNA sequencing (RNAseq). Factors secreted from cells treated conditioned media were analyzed by Luminex and ELISA. Role IL -. 11 in the SP-induced decidualizing assessed through Clustered interspaced regularly repeated palindromic short (CRISPR) / Cas-9-mediated knockout experiments in eSFs primary SP promoted decidualizing both in the absence and presence steroid hormone (P <0.05 compared to vehicle) with the necessary means seminal proteins.

amyloid semen does not promote decidualizing and induced a weak and transcriptomic responses in eSFs secretomic. Instead, fractionated SP enriched for semen microvesicles (MV) decidualizing promoted. IL – 11 is one of the most potent SP-induced gene in eSFs and important for decidualizing SP-facilitated <. Data AbstractText> RNAseq deposited in Gene Expression Omnibus repository with the serial number GSE135640 accession. This study is limited to in vitro analysis. Our results support the idea that the SP promotes decidualizing, including in eSFs of women with inflammatory disorders.

Active Interleukin 16 (IL16)

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Active Interleukin 23 (IL23)

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Active Interleukin 34 (IL34)

APC007Hu61 10ug
EUR 316

Active Interleukin 34 (IL34)

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Active Interleukin 29 (IL29)

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Description: Recombinant Human Interleukin 22 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 22 (IL22)

APC032Hu61 10ug
EUR 324

Active Interleukin 22 (IL22)

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Description: Recombinant Human Interleukin 20 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 20 (IL20)

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Active Interleukin 24 (IL24)

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Description: Recombinant Human Interleukin 24 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 10 (IL10)

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Active Interleukin 10 (IL10)

APA056Ca61 10ug
EUR 328

Active Interleukin 10 (IL10)

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Active Interleukin 10 (IL10)

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Active Interleukin 10 (IL10)

APA056Mu61 10ug
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Active Interleukin 10 (IL10)

APA056Ra01 10ug
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Active Interleukin 10 (IL10)

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Active Interleukin 10 (IL10)

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Description: Recombinant Human Interleukin 11 expressed in: E.coli

Active Interleukin 11 (IL11)

APA057Hu61 10ug
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Active Interleukin 11 (IL11)

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Active Interleukin 13 (IL13)

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Description: Recombinant Human Interleukin 15 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

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Description: Recombinant Human Interleukin 17 expressed in: E.coli

Active Interleukin 17 (IL17)

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Active Interleukin 17 (IL17)

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Description: Recombinant Human Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

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Description: Recombinant Mouse Interleukin 18 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Interleukin 32 (IL32)

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Active Interleukin 32 (IL32)

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EUR 3294.7

Active Interleukin 32 (IL32)

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EUR 522.7

Active Interleukin 19 (IL19)

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EUR 868.2

Active Interleukin 19 (IL19)

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EUR 3419.5

Active Interleukin 19 (IL19)

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EUR 542.5

Active Interleukin 10 (IL10)

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EUR 939.7

Active Interleukin 10 (IL10)

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EUR 3673.8

Active Interleukin 10 (IL10)

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EUR 587.2

Active Interleukin 31 (IL31)

RPU59177-100ug 100ug
EUR 1084.2

Active Interleukin 31 (IL31)

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EUR 4504.5

Active Interleukin 31 (IL31)

RPU59177-50ug 50ug
EUR 720

Active Interleukin 22 (IL22)

RPU59213-100ug 100ug
EUR 1069.2

Active Interleukin 22 (IL22)

RPU59213-1mg 1mg
EUR 4738.5

Active Interleukin 22 (IL22)

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EUR 712.8

Active Interleukin 10 (IL10)

RPU59216-100ug 100ug
EUR 1082.4

Active Interleukin 10 (IL10)

RPU59216-1mg 1mg
EUR 4797

Active Interleukin 10 (IL10)

RPU59216-50ug 50ug
EUR 721.6

Active Interleukin 11 (IL11)

RPU59219-100ug 100ug
EUR 1084.1

Active Interleukin 11 (IL11)

RPU59219-1mg 1mg
EUR 4802.9

Active Interleukin 11 (IL11)

RPU59219-50ug 50ug
EUR 722.5

Active Interleukin 26 (IL26)

RPU59230-100ug 100ug
EUR 1093.1

Active Interleukin 26 (IL26)

RPU59230-1mg 1mg
EUR 4843.8

Active Interleukin 26 (IL26)

RPU59230-50ug 50ug
EUR 728.6

Active Interleukin 13 (IL13)

RPU56351-100ug 100ug
EUR 985.6

Active Interleukin 13 (IL13)

RPU56351-1mg 1mg
EUR 4941.3

Active Interleukin 13 (IL13)

RPU56351-50ug 50ug
EUR 760.4

Active Interleukin 10 (IL10)

RPU56353-100ug 100ug
EUR 1282.6

Active Interleukin 10 (IL10)

RPU56353-1mg 1mg
EUR 5054.4

Active Interleukin 10 (IL10)

RPU56353-50ug 50ug
EUR 777.6

Active Interleukin 10 (IL10)

RPU56368-100ug 100ug
EUR 1078

Active Interleukin 10 (IL10)

RPU56368-1mg 1mg
EUR 4777.5

Active Interleukin 10 (IL10)

RPU56368-50ug 50ug
EUR 866.8

Active Interleukin 13 (IL13)

RPU55465-100ug 100ug
EUR 651.2

Active Interleukin 13 (IL13)

RPU55465-1mg 1mg
EUR 3294.2

Active Interleukin 13 (IL13)

RPU55465-50ug 50ug
EUR 506.9

Active Interleukin 18 (IL18)

RPU55467-100ug 100ug
EUR 739.2

Active Interleukin 18 (IL18)

RPU55467-1mg 1mg
EUR 3731

Active Interleukin 18 (IL18)

RPU55467-50ug 50ug
EUR 574.1

Active Interleukin 21 (IL21)

RPU55704-100ug 100ug
EUR 997.7

Active Interleukin 21 (IL21)

RPU55704-1mg 1mg
EUR 3893.5

Active Interleukin 21 (IL21)

RPU55704-50ug 50ug
EUR 599.1

Active Interleukin 33 (IL33)

RPU55739-100ug 100ug
EUR 1013.1

Active Interleukin 33 (IL33)

RPU55739-1mg 1mg
EUR 5116.8

Active Interleukin 33 (IL33)

RPU55739-50ug 50ug
EUR 787.2

Active Interleukin 34 (IL34)

RPU55743-100ug 100ug
EUR 997.7

Active Interleukin 34 (IL34)

RPU55743-1mg 1mg
EUR 3931.2

Despite the general ability of amyloid to induce cytokines known to be important for implantation, semen amyloid bad marks to decidualizing eSFs and do not promote them. In contrast, SP fractionated enriched for MV promoted transcription decidualizing and triggers a response in eSFs overlapping with the SP.

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Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits, Uncategorized, Vector & Virus, Western Blot

Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.

Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.

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